Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the lo...
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Main Authors: | Rémi Bos, Benoît Drouillas, Mouloud Bouhadfane, Emilie Pecchi, Virginie Trouplin, Sergiy M. Korogod, Frédéric Brocard |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/214612d1787d4019a823b0b8efb12a75 |
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