Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the article by Rao et al, this work elucidates how cytok...

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Autores principales:	Frank Michael Lehmann, Nicole von Burg, Robert Ivanek, Claudia Teufel, Edit Horvath, Annick Peter, Gleb Turchinovich, Daniel Staehli, Tobias Eichlisberger, Mercedes Gomez de Agüero, Mairene Coto-Llerena, Michaela Prchal-Murphy, Veronika Sexl, Mohamed Bentires-Alj, Christoph Mueller, Daniela Finke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/214732bb64544cc99449dba97da1e82b
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spelling	oai:doaj.org-article:214732bb64544cc99449dba97da1e82b2021-12-02T14:40:51ZMicrobiota-induced tissue signals regulate ILC3-mediated antigen presentation10.1038/s41467-020-15612-22041-1723https://doaj.org/article/214732bb64544cc99449dba97da1e82b2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15612-2https://doaj.org/toc/2041-1723Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the article by Rao et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.Frank Michael LehmannNicole von BurgRobert IvanekClaudia TeufelEdit HorvathAnnick PeterGleb TurchinovichDaniel StaehliTobias EichlisbergerMercedes Gomez de AgüeroMairene Coto-LlerenaMichaela Prchal-MurphyVeronika SexlMohamed Bentires-AljChristoph MuellerDaniela FinkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frank Michael Lehmann Nicole von Burg Robert Ivanek Claudia Teufel Edit Horvath Annick Peter Gleb Turchinovich Daniel Staehli Tobias Eichlisberger Mercedes Gomez de Agüero Mairene Coto-Llerena Michaela Prchal-Murphy Veronika Sexl Mohamed Bentires-Alj Christoph Mueller Daniela Finke Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
description	Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the article by Rao et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.
format	article
author	Frank Michael Lehmann Nicole von Burg Robert Ivanek Claudia Teufel Edit Horvath Annick Peter Gleb Turchinovich Daniel Staehli Tobias Eichlisberger Mercedes Gomez de Agüero Mairene Coto-Llerena Michaela Prchal-Murphy Veronika Sexl Mohamed Bentires-Alj Christoph Mueller Daniela Finke
author_facet	Frank Michael Lehmann Nicole von Burg Robert Ivanek Claudia Teufel Edit Horvath Annick Peter Gleb Turchinovich Daniel Staehli Tobias Eichlisberger Mercedes Gomez de Agüero Mairene Coto-Llerena Michaela Prchal-Murphy Veronika Sexl Mohamed Bentires-Alj Christoph Mueller Daniela Finke
author_sort	Frank Michael Lehmann
title	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
title_short	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
title_full	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
title_fullStr	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
title_full_unstemmed	Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation
title_sort	microbiota-induced tissue signals regulate ilc3-mediated antigen presentation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/214732bb64544cc99449dba97da1e82b
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Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

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