6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked...

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Autores principales:	Shunmin He, Guoqiang Zhang, Jiajia Wang, Yajie Gao, Ruidi Sun, Zhijie Cao, Zhenping Chen, Xiudeng Zheng, Jiao Yuan, Yuewan Luo, Xiaona Wang, Wenxin Zhang, Peng Zhang, Yi Zhao, Chuan He, Yi Tao, Qinmiao Sun, Dahua Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/214b9e5a5244411a9396133caa56244a
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spelling	oai:doaj.org-article:214b9e5a5244411a9396133caa56244a2021-12-02T15:36:00Z6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda10.1038/s41467-019-10202-32041-1723https://doaj.org/article/214b9e5a5244411a9396133caa56244a2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10202-3https://doaj.org/toc/2041-1723N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.Shunmin HeGuoqiang ZhangJiajia WangYajie GaoRuidi SunZhijie CaoZhenping ChenXiudeng ZhengJiao YuanYuewan LuoXiaona WangWenxin ZhangPeng ZhangYi ZhaoChuan HeYi TaoQinmiao SunDahua ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shunmin He Guoqiang Zhang Jiajia Wang Yajie Gao Ruidi Sun Zhijie Cao Zhenping Chen Xiudeng Zheng Jiao Yuan Yuewan Luo Xiaona Wang Wenxin Zhang Peng Zhang Yi Zhao Chuan He Yi Tao Qinmiao Sun Dahua Chen 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
description	N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.
format	article
author	Shunmin He Guoqiang Zhang Jiajia Wang Yajie Gao Ruidi Sun Zhijie Cao Zhenping Chen Xiudeng Zheng Jiao Yuan Yuewan Luo Xiaona Wang Wenxin Zhang Peng Zhang Yi Zhao Chuan He Yi Tao Qinmiao Sun Dahua Chen
author_facet	Shunmin He Guoqiang Zhang Jiajia Wang Yajie Gao Ruidi Sun Zhijie Cao Zhenping Chen Xiudeng Zheng Jiao Yuan Yuewan Luo Xiaona Wang Wenxin Zhang Peng Zhang Yi Zhao Chuan He Yi Tao Qinmiao Sun Dahua Chen
author_sort	Shunmin He
title	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
title_short	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
title_full	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
title_fullStr	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
title_full_unstemmed	6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
title_sort	6ma-dna-binding factor jumu controls maternal-to-zygotic transition upstream of zelda
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/214b9e5a5244411a9396133caa56244a
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6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

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