Macular phototoxicity after corneal cross-linking

Paulo Rodolfo Tagliari Barbisan,1 Marina Gonçalves Monteiro Viturino,1 Fernanda Maria Silveira Souto,1 Bo Tian,2,3 Roberto Damian Pacheco Pinto,1 Lucas Barasnevicius Quagliato,1 Maurício Abujamra Nascimento,1 Rosane Silvestre de Castro,1 Carlos Eduardo Leite Arieta1 1Departmen...

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Autores principales:	Barbisan PRT, Viturino MGM, Souto FMS, Tian B, Pinto RD, Quagliato LB, Nascimento MA, de Castro RS, Arieta CEL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	keratoconus light damage multifocal electroretinogram UVA. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/214f3fb3b09d4b66964e6452675ffcef
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spelling	oai:doaj.org-article:214f3fb3b09d4b66964e6452675ffcef2021-12-02T02:37:04ZMacular phototoxicity after corneal cross-linking1177-5483https://doaj.org/article/214f3fb3b09d4b66964e6452675ffcef2018-09-01T00:00:00Zhttps://www.dovepress.com/macular-phototoxicity-after-corneal-cross-linking-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Paulo Rodolfo Tagliari Barbisan,1 Marina Gonçalves Monteiro Viturino,1 Fernanda Maria Silveira Souto,1 Bo Tian,2,3 Roberto Damian Pacheco Pinto,1 Lucas Barasnevicius Quagliato,1 Maurício Abujamra Nascimento,1 Rosane Silvestre de Castro,1 Carlos Eduardo Leite Arieta1 1Department of Ophthalmology, State University of Campinas, Campinas, São Paulo, Brazil; 2Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 3Department of Ophthalmology and Visual Sciences, University of Massachusetts Medical School, Worcester, MA, USA Purpose: To assess potential vascular, structural, and functional changes to the macula in patients with keratoconus that underwent ultraviolet A (UVA)–riboflavin-mediated corneal collagen cross-linking (CXL) therapy.Patients and methods: Seventeen eyes from 17 patients of age 16 years or older with keratoconus undergoing CXL treatment were studied. The same eye served as its own control (before CXL vs after CXL). Eyes were evaluated in terms of best-corrected visual acuity (BCVA), refractive error, intraocular pressure, Amsler grid, retinography, fluorescein angiography, autofluorescence, and spectral domain optical coherence tomography (SD-OCT) prior to CXL and 7 and 30 days after treatment. Multifocal electroretinography (mfERG) was recorded prior to and 7 days after CXL.Results: Mean (SD) BCVA by logMAR chart was 0.47 (±0.12) pre-CXL, 0.55 (±0.15) 7 days post-CXL (P=0.57), and 0.46 (±0.10) 30 days post-CXL (P=0.87). Mean (SD) SD-OCT central macular thickness (µm) was 253.62 (±20.9) pre-CXL, 260.5 (±18.7) 7 days post-CXL (P=0.48), and 256.44 (±21.6) 30 days post-CXL (P=0.69). In 12 eyes, mfERG revealed a statistically significant increase (P=0.0353) in P1 latency (ms) of ring four from the pre-CXL period (39.45±2.05) to 7 days post-CXL (41.04±1.28) period. Regression analysis showed that the increase in P1 latency was correlated with the increase in central macular thickness (P=0.027). Furthermore, nine patients experienced a significant decrease in P1 amplitudes of rings 1 (P=0.0014), 2 (P=0.0029), 3 (P=0.0037), 4 (P=0.0014), and 5 (P=0.0012) from pre-CXL to 7 days post-CXL.Conclusion: In this pilot study, most of the patients exhibited slight changes in their mfERG parameters and OCT thickness, despite a lack of vascular abnormalities observed on fluorescein angiography/autofluorescence imaging, no alteration in BCVA, and no reports of symptoms. These changes could, therefore, be categorized as a mild subclinical effect of the corneal cross-linking procedure. Keywords: keratoconus, light damage, multifocal electroretinogram, UVA, phototoxicity, crosslinkingBarbisan PRTViturino MGMSouto FMSTian BPinto RDQuagliato LBNascimento MAde Castro RSArieta CELDove Medical Pressarticlekeratoconuslight damagemultifocal electroretinogramUVA.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1801-1807 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratoconus light damage multifocal electroretinogram UVA. Ophthalmology RE1-994
spellingShingle	keratoconus light damage multifocal electroretinogram UVA. Ophthalmology RE1-994 Barbisan PRT Viturino MGM Souto FMS Tian B Pinto RD Quagliato LB Nascimento MA de Castro RS Arieta CEL Macular phototoxicity after corneal cross-linking
description	Paulo Rodolfo Tagliari Barbisan,1 Marina Gonçalves Monteiro Viturino,1 Fernanda Maria Silveira Souto,1 Bo Tian,2,3 Roberto Damian Pacheco Pinto,1 Lucas Barasnevicius Quagliato,1 Maurício Abujamra Nascimento,1 Rosane Silvestre de Castro,1 Carlos Eduardo Leite Arieta1 1Department of Ophthalmology, State University of Campinas, Campinas, São Paulo, Brazil; 2Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 3Department of Ophthalmology and Visual Sciences, University of Massachusetts Medical School, Worcester, MA, USA Purpose: To assess potential vascular, structural, and functional changes to the macula in patients with keratoconus that underwent ultraviolet A (UVA)–riboflavin-mediated corneal collagen cross-linking (CXL) therapy.Patients and methods: Seventeen eyes from 17 patients of age 16 years or older with keratoconus undergoing CXL treatment were studied. The same eye served as its own control (before CXL vs after CXL). Eyes were evaluated in terms of best-corrected visual acuity (BCVA), refractive error, intraocular pressure, Amsler grid, retinography, fluorescein angiography, autofluorescence, and spectral domain optical coherence tomography (SD-OCT) prior to CXL and 7 and 30 days after treatment. Multifocal electroretinography (mfERG) was recorded prior to and 7 days after CXL.Results: Mean (SD) BCVA by logMAR chart was 0.47 (±0.12) pre-CXL, 0.55 (±0.15) 7 days post-CXL (P=0.57), and 0.46 (±0.10) 30 days post-CXL (P=0.87). Mean (SD) SD-OCT central macular thickness (µm) was 253.62 (±20.9) pre-CXL, 260.5 (±18.7) 7 days post-CXL (P=0.48), and 256.44 (±21.6) 30 days post-CXL (P=0.69). In 12 eyes, mfERG revealed a statistically significant increase (P=0.0353) in P1 latency (ms) of ring four from the pre-CXL period (39.45±2.05) to 7 days post-CXL (41.04±1.28) period. Regression analysis showed that the increase in P1 latency was correlated with the increase in central macular thickness (P=0.027). Furthermore, nine patients experienced a significant decrease in P1 amplitudes of rings 1 (P=0.0014), 2 (P=0.0029), 3 (P=0.0037), 4 (P=0.0014), and 5 (P=0.0012) from pre-CXL to 7 days post-CXL.Conclusion: In this pilot study, most of the patients exhibited slight changes in their mfERG parameters and OCT thickness, despite a lack of vascular abnormalities observed on fluorescein angiography/autofluorescence imaging, no alteration in BCVA, and no reports of symptoms. These changes could, therefore, be categorized as a mild subclinical effect of the corneal cross-linking procedure. Keywords: keratoconus, light damage, multifocal electroretinogram, UVA, phototoxicity, crosslinking
format	article
author	Barbisan PRT Viturino MGM Souto FMS Tian B Pinto RD Quagliato LB Nascimento MA de Castro RS Arieta CEL
author_facet	Barbisan PRT Viturino MGM Souto FMS Tian B Pinto RD Quagliato LB Nascimento MA de Castro RS Arieta CEL
author_sort	Barbisan PRT
title	Macular phototoxicity after corneal cross-linking
title_short	Macular phototoxicity after corneal cross-linking
title_full	Macular phototoxicity after corneal cross-linking
title_fullStr	Macular phototoxicity after corneal cross-linking
title_full_unstemmed	Macular phototoxicity after corneal cross-linking
title_sort	macular phototoxicity after corneal cross-linking
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/214f3fb3b09d4b66964e6452675ffcef
work_keys_str_mv	AT barbisanprt macularphototoxicityaftercornealcrosslinking AT viturinomgm macularphototoxicityaftercornealcrosslinking AT soutofms macularphototoxicityaftercornealcrosslinking AT tianb macularphototoxicityaftercornealcrosslinking AT pintord macularphototoxicityaftercornealcrosslinking AT quagliatolb macularphototoxicityaftercornealcrosslinking AT nascimentoma macularphototoxicityaftercornealcrosslinking AT decastrors macularphototoxicityaftercornealcrosslinking AT arietacel macularphototoxicityaftercornealcrosslinking
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Macular phototoxicity after corneal cross-linking

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