UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans

The mitochondrial network expands to accommodate cell growth, but how scaling occurs is unclear. Here, the authors show in C. elegans that ATFS-1 mitochondrial import is reduced when mitochondrial proteins are highly expressed, activating the unfolded protein response and causing expansion.

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Autores principales:	Tomer Shpilka, YunGuang Du, Qiyuan Yang, Andrew Melber, Nandhitha Uma Naresh, Joshua Lavelle, Sookyung Kim, Pengpeng Liu, Hilla Weidberg, Rui Li, Jun Yu, Lihua Julie Zhu, Lara Strittmatter, Cole M. Haynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21539f02bde640588b960f345e72c5ec
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spelling	oai:doaj.org-article:21539f02bde640588b960f345e72c5ec2021-12-02T14:18:55ZUPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans10.1038/s41467-020-20784-y2041-1723https://doaj.org/article/21539f02bde640588b960f345e72c5ec2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20784-yhttps://doaj.org/toc/2041-1723The mitochondrial network expands to accommodate cell growth, but how scaling occurs is unclear. Here, the authors show in C. elegans that ATFS-1 mitochondrial import is reduced when mitochondrial proteins are highly expressed, activating the unfolded protein response and causing expansion.Tomer ShpilkaYunGuang DuQiyuan YangAndrew MelberNandhitha Uma NareshJoshua LavelleSookyung KimPengpeng LiuHilla WeidbergRui LiJun YuLihua Julie ZhuLara StrittmatterCole M. HaynesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomer Shpilka YunGuang Du Qiyuan Yang Andrew Melber Nandhitha Uma Naresh Joshua Lavelle Sookyung Kim Pengpeng Liu Hilla Weidberg Rui Li Jun Yu Lihua Julie Zhu Lara Strittmatter Cole M. Haynes UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
description	The mitochondrial network expands to accommodate cell growth, but how scaling occurs is unclear. Here, the authors show in C. elegans that ATFS-1 mitochondrial import is reduced when mitochondrial proteins are highly expressed, activating the unfolded protein response and causing expansion.
format	article
author	Tomer Shpilka YunGuang Du Qiyuan Yang Andrew Melber Nandhitha Uma Naresh Joshua Lavelle Sookyung Kim Pengpeng Liu Hilla Weidberg Rui Li Jun Yu Lihua Julie Zhu Lara Strittmatter Cole M. Haynes
author_facet	Tomer Shpilka YunGuang Du Qiyuan Yang Andrew Melber Nandhitha Uma Naresh Joshua Lavelle Sookyung Kim Pengpeng Liu Hilla Weidberg Rui Li Jun Yu Lihua Julie Zhu Lara Strittmatter Cole M. Haynes
author_sort	Tomer Shpilka
title	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
title_short	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
title_full	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
title_fullStr	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
title_full_unstemmed	UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
title_sort	uprmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in caenorhabditis elegans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21539f02bde640588b960f345e72c5ec
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UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans

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