IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS

Significance of psoriasis (PS) research is determined by increasing incidence of this disorder, higher frequency of severe clinical forms, e.g., psoriatic arthritis (PsA). Clinical course and outcomes of psoriasis and psoriatic arthritis depend on degree of immunological disturbances and imbalance o...

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Autores principales:	S. V. Smirnova, M. V. Smolnikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	psoriasis psoriatic arthritis cytokines immunopathogenesis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/215e18b3b9d943f194cf620c6a2ff03a
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spelling	oai:doaj.org-article:215e18b3b9d943f194cf620c6a2ff03a2021-11-18T08:03:43ZIMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS1563-06252313-741X10.15789/1563-0625-2014-2-127-138https://doaj.org/article/215e18b3b9d943f194cf620c6a2ff03a2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/678https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSignificance of psoriasis (PS) research is determined by increasing incidence of this disorder, higher frequency of severe clinical forms, e.g., psoriatic arthritis (PsA). Clinical course and outcomes of psoriasis and psoriatic arthritis depend on degree of immunological disturbances and imbalance of cytokine regulation of intercellular interactions. The leading immune disorders involved in pathogenesis of psoriasis and PsA are those characterized by alterations of Th1-type cytokine profile (TNFα, IL-2, IFNγ, etc.). We have analyzed publications that reveal some features of PS and PsA immunopathogenesis associated with nature of the diseases. The review draws attention to relatively new and scarcely studied data concerning the role of cytokines produced by Th17- and Th22-cells (IL-17, IL-22, IL-23, IL-26), IL-19 subfamily (IL-19, IL-20, IL-24) in development of psoriasis and PsA. Search for the immunological markers predisposing for risk of psoriasis and PsA is an important step in personalized approach to their prediction and planning of preventive measures, in order to prevent progression of this pathology.S. V. SmirnovaM. V. SmolnikovaSPb RAACIarticlepsoriasispsoriatic arthritiscytokinesimmunopathogenesisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 127-138 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	psoriasis psoriatic arthritis cytokines immunopathogenesis Immunologic diseases. Allergy RC581-607
spellingShingle	psoriasis psoriatic arthritis cytokines immunopathogenesis Immunologic diseases. Allergy RC581-607 S. V. Smirnova M. V. Smolnikova IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
description	Significance of psoriasis (PS) research is determined by increasing incidence of this disorder, higher frequency of severe clinical forms, e.g., psoriatic arthritis (PsA). Clinical course and outcomes of psoriasis and psoriatic arthritis depend on degree of immunological disturbances and imbalance of cytokine regulation of intercellular interactions. The leading immune disorders involved in pathogenesis of psoriasis and PsA are those characterized by alterations of Th1-type cytokine profile (TNFα, IL-2, IFNγ, etc.). We have analyzed publications that reveal some features of PS and PsA immunopathogenesis associated with nature of the diseases. The review draws attention to relatively new and scarcely studied data concerning the role of cytokines produced by Th17- and Th22-cells (IL-17, IL-22, IL-23, IL-26), IL-19 subfamily (IL-19, IL-20, IL-24) in development of psoriasis and PsA. Search for the immunological markers predisposing for risk of psoriasis and PsA is an important step in personalized approach to their prediction and planning of preventive measures, in order to prevent progression of this pathology.
format	article
author	S. V. Smirnova M. V. Smolnikova
author_facet	S. V. Smirnova M. V. Smolnikova
author_sort	S. V. Smirnova
title	IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_short	IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_full	IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_fullStr	IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_full_unstemmed	IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS
title_sort	immune pathogenesis of psoriasis and psoriatic arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/215e18b3b9d943f194cf620c6a2ff03a
work_keys_str_mv	AT svsmirnova immunepathogenesisofpsoriasisandpsoriaticarthritis AT mvsmolnikova immunepathogenesisofpsoriasisandpsoriaticarthritis
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IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS

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