Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells.
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/21615c60190c416990f49adb86754ecf |
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oai:doaj.org-article:21615c60190c416990f49adb86754ecf2021-12-02T15:38:39ZParkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression10.1038/s41467-017-01947-w2041-1723https://doaj.org/article/21615c60190c416990f49adb86754ecf2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01947-whttps://doaj.org/toc/2041-1723Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells.Juan LiuCen ZhangYuhan ZhaoXuetian YueHao WuShan HuangJames ChenKyle TomskyHaiyang XieChristen A. KhellaMichael L. GatzaDajing XiaJimin GaoEileen WhiteBruce G. HafftyWenwei HuZhaohui FengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Juan Liu Cen Zhang Yuhan Zhao Xuetian Yue Hao Wu Shan Huang James Chen Kyle Tomsky Haiyang Xie Christen A. Khella Michael L. Gatza Dajing Xia Jimin Gao Eileen White Bruce G. Haffty Wenwei Hu Zhaohui Feng Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| description |
Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells. |
| format |
article |
| author |
Juan Liu Cen Zhang Yuhan Zhao Xuetian Yue Hao Wu Shan Huang James Chen Kyle Tomsky Haiyang Xie Christen A. Khella Michael L. Gatza Dajing Xia Jimin Gao Eileen White Bruce G. Haffty Wenwei Hu Zhaohui Feng |
| author_facet |
Juan Liu Cen Zhang Yuhan Zhao Xuetian Yue Hao Wu Shan Huang James Chen Kyle Tomsky Haiyang Xie Christen A. Khella Michael L. Gatza Dajing Xia Jimin Gao Eileen White Bruce G. Haffty Wenwei Hu Zhaohui Feng |
| author_sort |
Juan Liu |
| title |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| title_short |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| title_full |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| title_fullStr |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| title_full_unstemmed |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression |
| title_sort |
parkin targets hif-1α for ubiquitination and degradation to inhibit breast tumor progression |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/21615c60190c416990f49adb86754ecf |
| work_keys_str_mv |
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