Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?

Mohamed A Hendaus,1,2 Fatima A Jomha,3 Ahmed H Alhammadi1,2 1Department of Pediatrics, Section of Academic General Pediatrics, Hamad Medical Corporation, 2Department of Clinical Pediatrics, Weill-Cornell Medical College, Doha, Qatar; 3School of Pharmacy, Lebanese International University, Khiara, L...

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Autores principales:	Hendaus MA, Jomha FA, Alhammadi AH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	melatonin hypoxia use encephalopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/21671b229a0341f3974b45f00037b35e
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spelling	oai:doaj.org-article:21671b229a0341f3974b45f00037b35e2021-12-02T05:32:50ZMelatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?1178-2021https://doaj.org/article/21671b229a0341f3974b45f00037b35e2016-09-01T00:00:00Zhttps://www.dovepress.com/melatonin-in-the-management-of-perinatal-hypoxic-ischemic-encephalopat-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mohamed A Hendaus,1,2 Fatima A Jomha,3 Ahmed H Alhammadi1,2 1Department of Pediatrics, Section of Academic General Pediatrics, Hamad Medical Corporation, 2Department of Clinical Pediatrics, Weill-Cornell Medical College, Doha, Qatar; 3School of Pharmacy, Lebanese International University, Khiara, Lebanon Abstract: Perinatal hypoxic-ischemic encephalopathy (HIE) affects one to three per 1,000 live full-term births and can lead to severe and permanent neuropsychological sequelae, such as cerebral palsy, epilepsy, mental retardation, and visual motor or visual perceptive dysfunction. Melatonin has begun to be contemplated as a good choice in order to diminish the neurological sequelae from hypoxic-ischemic brain injury. Melatonin emerges as a very interesting medication, because of its capacity to cross all physiological barriers extending to subcellular compartments and its safety and effectiveness. The purpose of this commentary is to detail the evidence on the use of melatonin as a neuroprotection agent. The pharmacologic aspects of the drug as well as its potential neuroprotective characteristics in human and animal studies are described in this study. Melatonin seems to be safe and beneficial in protecting neonatal brains from perinatal HIE. Larger randomized controlled trials in humans are required, to implement a long-awaited feasible treatment in order to avoid the dreaded sequelae of HIE. Keywords: melatonin, hypoxia, use, encephalopathyHendaus MAJomha FAAlhammadi AHDove Medical PressarticlemelatoninhypoxiauseencephalopathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2473-2479 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	melatonin hypoxia use encephalopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	melatonin hypoxia use encephalopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hendaus MA Jomha FA Alhammadi AH Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
description	Mohamed A Hendaus,1,2 Fatima A Jomha,3 Ahmed H Alhammadi1,2 1Department of Pediatrics, Section of Academic General Pediatrics, Hamad Medical Corporation, 2Department of Clinical Pediatrics, Weill-Cornell Medical College, Doha, Qatar; 3School of Pharmacy, Lebanese International University, Khiara, Lebanon Abstract: Perinatal hypoxic-ischemic encephalopathy (HIE) affects one to three per 1,000 live full-term births and can lead to severe and permanent neuropsychological sequelae, such as cerebral palsy, epilepsy, mental retardation, and visual motor or visual perceptive dysfunction. Melatonin has begun to be contemplated as a good choice in order to diminish the neurological sequelae from hypoxic-ischemic brain injury. Melatonin emerges as a very interesting medication, because of its capacity to cross all physiological barriers extending to subcellular compartments and its safety and effectiveness. The purpose of this commentary is to detail the evidence on the use of melatonin as a neuroprotection agent. The pharmacologic aspects of the drug as well as its potential neuroprotective characteristics in human and animal studies are described in this study. Melatonin seems to be safe and beneficial in protecting neonatal brains from perinatal HIE. Larger randomized controlled trials in humans are required, to implement a long-awaited feasible treatment in order to avoid the dreaded sequelae of HIE. Keywords: melatonin, hypoxia, use, encephalopathy
format	article
author	Hendaus MA Jomha FA Alhammadi AH
author_facet	Hendaus MA Jomha FA Alhammadi AH
author_sort	Hendaus MA
title	Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
title_short	Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
title_full	Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
title_fullStr	Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
title_full_unstemmed	Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
title_sort	melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/21671b229a0341f3974b45f00037b35e
work_keys_str_mv	AT hendausma melatonininthemanagementofperinatalhypoxicischemicencephalopathylightattheendofthetunnel AT jomhafa melatonininthemanagementofperinatalhypoxicischemicencephalopathylightattheendofthetunnel AT alhammadiah melatonininthemanagementofperinatalhypoxicischemicencephalopathylightattheendofthetunnel
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Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?

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