ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

The expression of the oncogene Myc is carefully controlled and dysregulation often leads to cancer. Here, the authors describe an E3 ligase for Myc—ELL—and show that it likely controls the ubiquitination and degradation of Myc.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Chen, Chi Zhou, Wei Ji, Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2167e5b4fc6f436d93e5b23325c17d9c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2167e5b4fc6f436d93e5b23325c17d9c
record_format	dspace
spelling	oai:doaj.org-article:2167e5b4fc6f436d93e5b23325c17d9c2021-12-02T15:35:20ZELL targets c-Myc for proteasomal degradation and suppresses tumour growth10.1038/ncomms110572041-1723https://doaj.org/article/2167e5b4fc6f436d93e5b23325c17d9c2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11057https://doaj.org/toc/2041-1723The expression of the oncogene Myc is carefully controlled and dysregulation often leads to cancer. Here, the authors describe an E3 ligase for Myc—ELL—and show that it likely controls the ubiquitination and degradation of Myc.Yu ChenChi ZhouWei JiZhichao MeiBo HuWei ZhangDawei ZhangJing WangXing LiuGang OuyangJiangang ZhouWuhan XiaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Chen Chi Zhou Wei Ji Zhichao Mei Bo Hu Wei Zhang Dawei Zhang Jing Wang Xing Liu Gang Ouyang Jiangang Zhou Wuhan Xiao ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
description	The expression of the oncogene Myc is carefully controlled and dysregulation often leads to cancer. Here, the authors describe an E3 ligase for Myc—ELL—and show that it likely controls the ubiquitination and degradation of Myc.
format	article
author	Yu Chen Chi Zhou Wei Ji Zhichao Mei Bo Hu Wei Zhang Dawei Zhang Jing Wang Xing Liu Gang Ouyang Jiangang Zhou Wuhan Xiao
author_facet	Yu Chen Chi Zhou Wei Ji Zhichao Mei Bo Hu Wei Zhang Dawei Zhang Jing Wang Xing Liu Gang Ouyang Jiangang Zhou Wuhan Xiao
author_sort	Yu Chen
title	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
title_short	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
title_full	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
title_fullStr	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
title_full_unstemmed	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth
title_sort	ell targets c-myc for proteasomal degradation and suppresses tumour growth
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2167e5b4fc6f436d93e5b23325c17d9c
work_keys_str_mv	AT yuchen elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT chizhou elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT weiji elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT zhichaomei elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT bohu elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT weizhang elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT daweizhang elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT jingwang elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT xingliu elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT gangouyang elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT jiangangzhou elltargetscmycforproteasomaldegradationandsuppressestumourgrowth AT wuhanxiao elltargetscmycforproteasomaldegradationandsuppressestumourgrowth
_version_	1718386583601676288

ELL targets c-Myc for proteasomal degradation and suppresses tumour growth

Ejemplares similares