Highly efficient RNA-guided base editing in rabbit

Highly efficient RNA-guided base editing in rabbit

Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-G...

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Autores principales: Zhiquan Liu, Mao Chen, Siyu Chen, Jichao Deng, Yuning Song, Liangxue Lai, Zhanjun Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/216e4fab831c49e88ba047feee841317
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spelling oai:doaj.org-article:216e4fab831c49e88ba047feee8413172021-12-02T16:49:49ZHighly efficient RNA-guided base editing in rabbit10.1038/s41467-018-05232-22041-1723https://doaj.org/article/216e4fab831c49e88ba047feee8413172018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05232-2https://doaj.org/toc/2041-1723Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.Zhiquan LiuMao ChenSiyu ChenJichao DengYuning SongLiangxue LaiZhanjun LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhiquan Liu
Mao Chen
Siyu Chen
Jichao Deng
Yuning Song
Liangxue Lai
Zhanjun Li
Highly efficient RNA-guided base editing in rabbit
description Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.
format article
author Zhiquan Liu
Mao Chen
Siyu Chen
Jichao Deng
Yuning Song
Liangxue Lai
Zhanjun Li
author_facet Zhiquan Liu
Mao Chen
Siyu Chen
Jichao Deng
Yuning Song
Liangxue Lai
Zhanjun Li
author_sort Zhiquan Liu
title Highly efficient RNA-guided base editing in rabbit
title_short Highly efficient RNA-guided base editing in rabbit
title_full Highly efficient RNA-guided base editing in rabbit
title_fullStr Highly efficient RNA-guided base editing in rabbit
title_full_unstemmed Highly efficient RNA-guided base editing in rabbit
title_sort highly efficient rna-guided base editing in rabbit
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/216e4fab831c49e88ba047feee841317
work_keys_str_mv AT zhiquanliu highlyefficientrnaguidedbaseeditinginrabbit
AT maochen highlyefficientrnaguidedbaseeditinginrabbit
AT siyuchen highlyefficientrnaguidedbaseeditinginrabbit
AT jichaodeng highlyefficientrnaguidedbaseeditinginrabbit
AT yuningsong highlyefficientrnaguidedbaseeditinginrabbit
AT liangxuelai highlyefficientrnaguidedbaseeditinginrabbit
AT zhanjunli highlyefficientrnaguidedbaseeditinginrabbit
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