Highly efficient RNA-guided base editing in rabbit

Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-G...

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Auteurs principaux: Zhiquan Liu, Mao Chen, Siyu Chen, Jichao Deng, Yuning Song, Liangxue Lai, Zhanjun Li
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/216e4fab831c49e88ba047feee841317
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