miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2

This study mainly explores how miR-183-5p pertains to breast cancer (BC) development. Functional assays were employed to test impacts of miR-183-5p in this cancer. Targeting between RGS2 and miR-183-5p was examined with dual-luciferase assay, and how their interaction pertains to cancer progression...

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Autores principales:	Chihua Wu, Youlin Tuo, Gang Hu, Jing Luo
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Computer applications to medicine. Medical informatics R858-859.7
Acceso en línea:	https://doaj.org/article/2170496e51384586bb5fc1c09422d42c
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spelling	oai:doaj.org-article:2170496e51384586bb5fc1c09422d42c2021-11-29T00:56:16ZmiR-183-5p Aggravates Breast Cancer Development via Mediation of RGS21748-671810.1155/2021/9664195https://doaj.org/article/2170496e51384586bb5fc1c09422d42c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9664195https://doaj.org/toc/1748-6718This study mainly explores how miR-183-5p pertains to breast cancer (BC) development. Functional assays were employed to test impacts of miR-183-5p in this cancer. Targeting between RGS2 and miR-183-5p was examined with dual-luciferase assay, and how their interaction pertains to cancer progression was further unraveled. miR-183-5p level was noticeably high in cancer tissue/cells. Overexpressing miR-183-5p could remarkably deteriorate cancer progression. The regulatory gene RGS2 levels was markedly low in BC, and two genes we researched were negatively correlated. It was uncovered by rescue assay that miR-183-5p/RGS2 axis mediated tumor-relevant behaviors in BC. Altogether, miR-183-5p aggravates BC development via mediation of RGS2. miR-183-5p supplies a promising target for BC therapy.Chihua WuYoulin TuoGang HuJing LuoHindawi LimitedarticleComputer applications to medicine. Medical informaticsR858-859.7ENComputational and Mathematical Methods in Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Computer applications to medicine. Medical informatics R858-859.7
spellingShingle	Computer applications to medicine. Medical informatics R858-859.7 Chihua Wu Youlin Tuo Gang Hu Jing Luo miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
description	This study mainly explores how miR-183-5p pertains to breast cancer (BC) development. Functional assays were employed to test impacts of miR-183-5p in this cancer. Targeting between RGS2 and miR-183-5p was examined with dual-luciferase assay, and how their interaction pertains to cancer progression was further unraveled. miR-183-5p level was noticeably high in cancer tissue/cells. Overexpressing miR-183-5p could remarkably deteriorate cancer progression. The regulatory gene RGS2 levels was markedly low in BC, and two genes we researched were negatively correlated. It was uncovered by rescue assay that miR-183-5p/RGS2 axis mediated tumor-relevant behaviors in BC. Altogether, miR-183-5p aggravates BC development via mediation of RGS2. miR-183-5p supplies a promising target for BC therapy.
format	article
author	Chihua Wu Youlin Tuo Gang Hu Jing Luo
author_facet	Chihua Wu Youlin Tuo Gang Hu Jing Luo
author_sort	Chihua Wu
title	miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
title_short	miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
title_full	miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
title_fullStr	miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
title_full_unstemmed	miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2
title_sort	mir-183-5p aggravates breast cancer development via mediation of rgs2
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2170496e51384586bb5fc1c09422d42c
work_keys_str_mv	AT chihuawu mir1835paggravatesbreastcancerdevelopmentviamediationofrgs2 AT youlintuo mir1835paggravatesbreastcancerdevelopmentviamediationofrgs2 AT ganghu mir1835paggravatesbreastcancerdevelopmentviamediationofrgs2 AT jingluo mir1835paggravatesbreastcancerdevelopmentviamediationofrgs2
_version_	1718407693380616192

miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2

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