Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2

Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication...

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Autores principales:	Rebecca Harris, Jianjun Yang, Kassandra Pagan, Soo Jung Cho, Heather Stout-Delgado
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antiviral H3N2 H1N1 influenza aging lung Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/21729b9ad8a840149e3565fddd7b7402
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spelling	oai:doaj.org-article:21729b9ad8a840149e3565fddd7b74022021-11-25T17:53:23ZAntiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N210.3390/ijms2222120971422-00671661-6596https://doaj.org/article/21729b9ad8a840149e3565fddd7b74022021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12097https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication and guide the initiation of adaptive immune responses. Using young adult (3 months) and aged adult mice infected with mouse adapted H1N1 or H3N2, the results of our study illustrate dysregulated and/or diminished activation of key signaling pathways in aged lung contribute to increased lung inflammation and morbidity. Specifically, within the first seven days of infection, there were significant changes in genes associated with TLR and RIG-I signaling detected in aged murine lung in response to H1N1 or H3N2. Taken together, the results of our study expand our current understanding of age-associated changes in antiviral signaling in the lung.Rebecca HarrisJianjun YangKassandra PaganSoo Jung ChoHeather Stout-DelgadoMDPI AGarticleantiviralH3N2H1N1influenzaaginglungBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12097, p 12097 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiviral H3N2 H1N1 influenza aging lung Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antiviral H3N2 H1N1 influenza aging lung Biology (General) QH301-705.5 Chemistry QD1-999 Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
description	Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication and guide the initiation of adaptive immune responses. Using young adult (3 months) and aged adult mice infected with mouse adapted H1N1 or H3N2, the results of our study illustrate dysregulated and/or diminished activation of key signaling pathways in aged lung contribute to increased lung inflammation and morbidity. Specifically, within the first seven days of infection, there were significant changes in genes associated with TLR and RIG-I signaling detected in aged murine lung in response to H1N1 or H3N2. Taken together, the results of our study expand our current understanding of age-associated changes in antiviral signaling in the lung.
format	article
author	Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado
author_facet	Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado
author_sort	Rebecca Harris
title	Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
title_short	Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
title_full	Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
title_fullStr	Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
title_full_unstemmed	Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
title_sort	antiviral gene expression in young and aged murine lung during h1n1 and h3n2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/21729b9ad8a840149e3565fddd7b7402
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Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2

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