Change in body size and mortality: results from the Melbourne collaborative cohort study.

<h4>Background</h4>The association between change in weight or body mass index, and mortality is widely reported, however, both measures fail to account for fat distribution. Change in waist circumference, a measure of central adiposity, in relation to mortality has not been studied exte...

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Autores principales:	Amalia Karahalios, Julie A Simpson, Laura Baglietto, Robert J MacInnis, Allison M Hodge, Graham G Giles, Dallas R English
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21739a5444454f31b05106c163465b76
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spelling	oai:doaj.org-article:21739a5444454f31b05106c163465b762021-11-25T06:09:52ZChange in body size and mortality: results from the Melbourne collaborative cohort study.1932-620310.1371/journal.pone.0099672https://doaj.org/article/21739a5444454f31b05106c163465b762014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24988430/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The association between change in weight or body mass index, and mortality is widely reported, however, both measures fail to account for fat distribution. Change in waist circumference, a measure of central adiposity, in relation to mortality has not been studied extensively.<h4>Methods</h4>We investigated the association between mortality and changes in directly measured waist circumference, hips circumference and weight from baseline (1990-1994) to wave 2 (2003-2007) in a prospective cohort study of people aged 40-69 years at baseline. Cox regression, with age as the time metric and follow-up starting at wave 2, adjusted for confounding variables, was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for change in body size in relation to mortality from all causes, cardiovascular disease and cancer.<h4>Results</h4>There were 1465 deaths (109 cancer, 242 cardiovascular disease) identified during an average 7.7 years of follow-up from 21 298 participants. Compared to minimal increase in body size, loss of waist circumference (HR: 1.26; 95% CI: 1.09-1.47), weight (1.80; 1.54-2.11), or hips circumference (1.35; 1.15-1.57) were associated with an increased risk of all-cause mortality, particularly for older adults. Weight loss was associated with cardiovascular disease mortality (2.40; 1.57-3.65) but change in body size was not associated with obesity-related cancer mortality.<h4>Conclusion</h4>This study confirms the association between weight loss and increased mortality from all-causes for older adults. Based on evidence from observational cohort studies, weight stability may be the recommended option for most adults, especially older adults.Amalia KarahaliosJulie A SimpsonLaura BagliettoRobert J MacInnisAllison M HodgeGraham G GilesDallas R EnglishPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e99672 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amalia Karahalios Julie A Simpson Laura Baglietto Robert J MacInnis Allison M Hodge Graham G Giles Dallas R English Change in body size and mortality: results from the Melbourne collaborative cohort study.
description	<h4>Background</h4>The association between change in weight or body mass index, and mortality is widely reported, however, both measures fail to account for fat distribution. Change in waist circumference, a measure of central adiposity, in relation to mortality has not been studied extensively.<h4>Methods</h4>We investigated the association between mortality and changes in directly measured waist circumference, hips circumference and weight from baseline (1990-1994) to wave 2 (2003-2007) in a prospective cohort study of people aged 40-69 years at baseline. Cox regression, with age as the time metric and follow-up starting at wave 2, adjusted for confounding variables, was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for change in body size in relation to mortality from all causes, cardiovascular disease and cancer.<h4>Results</h4>There were 1465 deaths (109 cancer, 242 cardiovascular disease) identified during an average 7.7 years of follow-up from 21 298 participants. Compared to minimal increase in body size, loss of waist circumference (HR: 1.26; 95% CI: 1.09-1.47), weight (1.80; 1.54-2.11), or hips circumference (1.35; 1.15-1.57) were associated with an increased risk of all-cause mortality, particularly for older adults. Weight loss was associated with cardiovascular disease mortality (2.40; 1.57-3.65) but change in body size was not associated with obesity-related cancer mortality.<h4>Conclusion</h4>This study confirms the association between weight loss and increased mortality from all-causes for older adults. Based on evidence from observational cohort studies, weight stability may be the recommended option for most adults, especially older adults.
format	article
author	Amalia Karahalios Julie A Simpson Laura Baglietto Robert J MacInnis Allison M Hodge Graham G Giles Dallas R English
author_facet	Amalia Karahalios Julie A Simpson Laura Baglietto Robert J MacInnis Allison M Hodge Graham G Giles Dallas R English
author_sort	Amalia Karahalios
title	Change in body size and mortality: results from the Melbourne collaborative cohort study.
title_short	Change in body size and mortality: results from the Melbourne collaborative cohort study.
title_full	Change in body size and mortality: results from the Melbourne collaborative cohort study.
title_fullStr	Change in body size and mortality: results from the Melbourne collaborative cohort study.
title_full_unstemmed	Change in body size and mortality: results from the Melbourne collaborative cohort study.
title_sort	change in body size and mortality: results from the melbourne collaborative cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/21739a5444454f31b05106c163465b76
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Change in body size and mortality: results from the Melbourne collaborative cohort study.

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