EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY

Objective: To observe the effect of dutasteridein decreasing surgical blood loss following unipolar transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH). Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospita...

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Autores principales: Mujahid Ali Khoso, Sumeera Matee, Saeed Bin Ayaz
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Publicado: Army Medical College Rawalpindi 2019
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spelling oai:doaj.org-article:2173ba9ec74a47bb8292a2b6499beeb82021-11-09T03:40:46ZEFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY0030-96482411-8842https://doaj.org/article/2173ba9ec74a47bb8292a2b6499beeb82019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3411/2386https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To observe the effect of dutasteridein decreasing surgical blood loss following unipolar transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH). Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital, Quetta Pakistan, from Jul 2017 to Mar 2018. Methodology: 66 BPH patients were consecutively reunited. Six patients declined participation while 4 wereexcluded because of chronic kidney disease and/or a bleeding disorder. The included patients underwent an evaluation for hematocrit, serum urea and creatinine, and international normalized ratio. Four patients with impaired renal functions or altered coagulation parameters were also excluded. Patients taking non-steroidal antiinflammatory drugs and anticoagulant/antiplatelet drugs discontinued these drugs two weeks prior to TURP. After block randomization,the control group was given tablet tamsulosin hydrochloride 0.4 mg once daily while the target group was provided tablet tamsulosin hydrochloride 0.4 mg and dutasteride 0.5 mg orally once daily. All patients started the drugs two weeks before the operation. TURP was carried out under spinal anesthesia. At 48 h after TURP, a blood sample was revaluated for hematocrit. The resected prostatic tissue was measured. Results: The mean age of the patients was 68.3 ± 8.4 (range: 50-90 years). The mean hematocrit before operation was 0.42% ± 0.04% (range: 0.31%-0.53%) while themean hematocrit after the operation was 0.38% ± 0.04% (range: 0.28%-0.47%). The mean prostatic tissue removed during TURP was 22.3 ± 11.6 g (range: 7-54 g). The mean hematocrit reduction was 0.05% ± 0.02% (range: 0.1%-0.02%) and the mean hematocrit reduction per gram of prostatic tissue removed was 547.2 ± 355.1%/g (range: 1666.7%/g – 100%/g). After statistical analysis, there was no significant difference for the mean reduction in hematocrit (p=0.59). Conclusion: Dutasteride at a dose of 0.4 mg per day did not produce significant reduction in relative blood loss and relative blood loss per gram of prostatic tissue removed with 2-weeks pretreatment before unipolar TURP in patients with BPH.Mujahid Ali KhosoSumeera MateeSaeed Bin AyazArmy Medical College Rawalpindiarticleprostatic hyperplasiadutasteridehematocritsurgical blood lossMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1047-1050 (2019)
institution DOAJ
collection DOAJ
language EN
topic prostatic hyperplasia
dutasteride
hematocrit
surgical blood loss
Medicine
R
Medicine (General)
R5-920
spellingShingle prostatic hyperplasia
dutasteride
hematocrit
surgical blood loss
Medicine
R
Medicine (General)
R5-920
Mujahid Ali Khoso
Sumeera Matee
Saeed Bin Ayaz
EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
description Objective: To observe the effect of dutasteridein decreasing surgical blood loss following unipolar transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH). Study Design: Quasi experimental study. Place and Duration of Study: Combined Military Hospital, Quetta Pakistan, from Jul 2017 to Mar 2018. Methodology: 66 BPH patients were consecutively reunited. Six patients declined participation while 4 wereexcluded because of chronic kidney disease and/or a bleeding disorder. The included patients underwent an evaluation for hematocrit, serum urea and creatinine, and international normalized ratio. Four patients with impaired renal functions or altered coagulation parameters were also excluded. Patients taking non-steroidal antiinflammatory drugs and anticoagulant/antiplatelet drugs discontinued these drugs two weeks prior to TURP. After block randomization,the control group was given tablet tamsulosin hydrochloride 0.4 mg once daily while the target group was provided tablet tamsulosin hydrochloride 0.4 mg and dutasteride 0.5 mg orally once daily. All patients started the drugs two weeks before the operation. TURP was carried out under spinal anesthesia. At 48 h after TURP, a blood sample was revaluated for hematocrit. The resected prostatic tissue was measured. Results: The mean age of the patients was 68.3 ± 8.4 (range: 50-90 years). The mean hematocrit before operation was 0.42% ± 0.04% (range: 0.31%-0.53%) while themean hematocrit after the operation was 0.38% ± 0.04% (range: 0.28%-0.47%). The mean prostatic tissue removed during TURP was 22.3 ± 11.6 g (range: 7-54 g). The mean hematocrit reduction was 0.05% ± 0.02% (range: 0.1%-0.02%) and the mean hematocrit reduction per gram of prostatic tissue removed was 547.2 ± 355.1%/g (range: 1666.7%/g – 100%/g). After statistical analysis, there was no significant difference for the mean reduction in hematocrit (p=0.59). Conclusion: Dutasteride at a dose of 0.4 mg per day did not produce significant reduction in relative blood loss and relative blood loss per gram of prostatic tissue removed with 2-weeks pretreatment before unipolar TURP in patients with BPH.
format article
author Mujahid Ali Khoso
Sumeera Matee
Saeed Bin Ayaz
author_facet Mujahid Ali Khoso
Sumeera Matee
Saeed Bin Ayaz
author_sort Mujahid Ali Khoso
title EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
title_short EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
title_full EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
title_fullStr EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
title_full_unstemmed EFFECT OF DUTASTERIDE IN DECREASING SURGICAL BLOOD LOSS FOLLOWING UNIPOLAR TRANSURETHRAL RESECTION OF PROSTATEIN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: A QUASI EXPERIMENTAL STUDY
title_sort effect of dutasteride in decreasing surgical blood loss following unipolar transurethral resection of prostatein patients with benign prostatic hyperplasia: a quasi experimental study
publisher Army Medical College Rawalpindi
publishDate 2019
url https://doaj.org/article/2173ba9ec74a47bb8292a2b6499beeb8
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