Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico

Karina Gonzalez-Aldaco, Sonia Roman, Luis A Torres-Reyes, Arturo Panduro Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoCorrespondence: Arturo Pandur...

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Autores principales:	Gonzalez-Aldaco K, Roman S, Torres-Reyes LA, Panduro A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	apoe obesity dyslipidemia nutritional transition hepatopathogenic diet homa-ir. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/217b6762e4e0418e951429897e7fed10
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spelling	oai:doaj.org-article:217b6762e4e0418e951429897e7fed102021-12-02T12:59:32ZAssociation of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico1178-7007https://doaj.org/article/217b6762e4e0418e951429897e7fed102020-10-01T00:00:00Zhttps://www.dovepress.com/association-of-apolipoprotein-e2-allele-with-insulin-resistance-and-ri-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Karina Gonzalez-Aldaco, Sonia Roman, Luis A Torres-Reyes, Arturo Panduro Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoCorrespondence: Arturo PanduroDepartment of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde” and Health Sciences University Center, University of Guadalajara, Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, MexicoTel/fax +52-33-36-14-77-43Email apanduro@prodigy.net.mxPurpose: This study aimed to analyze the association of the apolipoprotein E (ApoE) polymorphisms with type 2 diabetes mellitus (T2DM) among the admixed population of West Mexico.Patients and Methods: ApoE genotypes were determined in 168 T2DM patients and 449 non-diabetic control subjects from the general admixed population of West Mexico. The non-diabetic subjects were stratified according to body mass index (BMI) in normal weight (n=186), overweight (n=138), and obesity (n=125). ApoE genotypes were assessed by using a TaqMan allelic discrimination assay, insulin resistance (IR) by HOMA-IR, and biochemistry with a dry chemistry assay.Results: The rate of dyslipidemias and IR increased by BMI category among the control subjects. The greater shift in the prevalence of dyslipidemia was observed from normal weight (51.4%) to overweight (76.6%), p< 0.01. Normal weight or obese e4 allele carriers had a higher level of total cholesterol and hypercholesterolemia than non-e4 carriers. Among the T2DM patients, the e2 carriers had abnormal HOMA-IR value than the non-e2 carriers (p=0.002). Comparatively, between the T2DM patients vs non-diabetics, the e2e3 genotype or e2 allele conferred a higher risk for T2DM (adjusted OR= 2.36, 95% CI 1.28– 4.34, p=0.006 and adjusted OR=2.1, 95% Cl 1.20– 3.79, p=0.009, respectively).Conclusion: The ApoE e2 allele was associated with IR and the risk of T2DM in subjects from the general admixed population of West Mexico.Keywords: ApoE, obesity, dyslipidemia, nutritional transition, hepatopathogenic diet, HOMA-IRGonzalez-Aldaco KRoman STorres-Reyes LAPanduro ADove Medical Pressarticleapoeobesitydyslipidemianutritional transitionhepatopathogenic diethoma-ir.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3527-3534 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoe obesity dyslipidemia nutritional transition hepatopathogenic diet homa-ir. Specialties of internal medicine RC581-951
spellingShingle	apoe obesity dyslipidemia nutritional transition hepatopathogenic diet homa-ir. Specialties of internal medicine RC581-951 Gonzalez-Aldaco K Roman S Torres-Reyes LA Panduro A Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
description	Karina Gonzalez-Aldaco, Sonia Roman, Luis A Torres-Reyes, Arturo Panduro Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, MexicoCorrespondence: Arturo PanduroDepartment of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde” and Health Sciences University Center, University of Guadalajara, Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, MexicoTel/fax +52-33-36-14-77-43Email apanduro@prodigy.net.mxPurpose: This study aimed to analyze the association of the apolipoprotein E (ApoE) polymorphisms with type 2 diabetes mellitus (T2DM) among the admixed population of West Mexico.Patients and Methods: ApoE genotypes were determined in 168 T2DM patients and 449 non-diabetic control subjects from the general admixed population of West Mexico. The non-diabetic subjects were stratified according to body mass index (BMI) in normal weight (n=186), overweight (n=138), and obesity (n=125). ApoE genotypes were assessed by using a TaqMan allelic discrimination assay, insulin resistance (IR) by HOMA-IR, and biochemistry with a dry chemistry assay.Results: The rate of dyslipidemias and IR increased by BMI category among the control subjects. The greater shift in the prevalence of dyslipidemia was observed from normal weight (51.4%) to overweight (76.6%), p< 0.01. Normal weight or obese e4 allele carriers had a higher level of total cholesterol and hypercholesterolemia than non-e4 carriers. Among the T2DM patients, the e2 carriers had abnormal HOMA-IR value than the non-e2 carriers (p=0.002). Comparatively, between the T2DM patients vs non-diabetics, the e2e3 genotype or e2 allele conferred a higher risk for T2DM (adjusted OR= 2.36, 95% CI 1.28– 4.34, p=0.006 and adjusted OR=2.1, 95% Cl 1.20– 3.79, p=0.009, respectively).Conclusion: The ApoE e2 allele was associated with IR and the risk of T2DM in subjects from the general admixed population of West Mexico.Keywords: ApoE, obesity, dyslipidemia, nutritional transition, hepatopathogenic diet, HOMA-IR
format	article
author	Gonzalez-Aldaco K Roman S Torres-Reyes LA Panduro A
author_facet	Gonzalez-Aldaco K Roman S Torres-Reyes LA Panduro A
author_sort	Gonzalez-Aldaco K
title	Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
title_short	Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
title_full	Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
title_fullStr	Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
title_full_unstemmed	Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico
title_sort	association of apolipoprotein e2 allele with insulin resistance and risk of type 2 diabetes mellitus among an admixed population of mexico
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/217b6762e4e0418e951429897e7fed10
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Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico

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