A systematic exploration of the interactions between bacterial effector proteins and host cell membranes
Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.
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Nature Portfolio
2017
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oai:doaj.org-article:217bfd32a26b4c0bb9b8f8ae3db9c3fe2021-12-02T14:42:11ZA systematic exploration of the interactions between bacterial effector proteins and host cell membranes10.1038/s41467-017-00700-72041-1723https://doaj.org/article/217bfd32a26b4c0bb9b8f8ae3db9c3fe2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00700-7https://doaj.org/toc/2041-1723Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.Bethany A. WeigeleRobert C. OrchardAlyssa JimenezGregory W. CoxNeal M. AltoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q Bethany A. Weigele Robert C. Orchard Alyssa Jimenez Gregory W. Cox Neal M. Alto A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
description |
Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles. |
format |
article |
author |
Bethany A. Weigele Robert C. Orchard Alyssa Jimenez Gregory W. Cox Neal M. Alto |
author_facet |
Bethany A. Weigele Robert C. Orchard Alyssa Jimenez Gregory W. Cox Neal M. Alto |
author_sort |
Bethany A. Weigele |
title |
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
title_short |
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
title_full |
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
title_fullStr |
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
title_full_unstemmed |
A systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
title_sort |
systematic exploration of the interactions between bacterial effector proteins and host cell membranes |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/217bfd32a26b4c0bb9b8f8ae3db9c3fe |
work_keys_str_mv |
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1718389738684022784 |