NMR Studies of Tau Protein in Tauopathies

Tauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline an...

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Autores principales:	Kristine Kitoka, Rostislav Skrabana, Norbert Gasparik, Jozef Hritz, Kristaps Jaudzems
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tau nuclear magnetic resonance protein structure Alzheimer’s disease filaments Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/217c956f629f478a813ac5043d5e8955
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spelling	oai:doaj.org-article:217c956f629f478a813ac5043d5e89552021-11-11T10:25:34ZNMR Studies of Tau Protein in Tauopathies2296-889X10.3389/fmolb.2021.761227https://doaj.org/article/217c956f629f478a813ac5043d5e89552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.761227/fullhttps://doaj.org/toc/2296-889XTauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.Kristine KitokaRostislav SkrabanaRostislav SkrabanaNorbert GasparikNorbert GasparikJozef HritzJozef HritzKristaps JaudzemsKristaps JaudzemsFrontiers Media S.A.articletaunuclear magnetic resonanceprotein structureAlzheimer’s diseasefilamentsBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tau nuclear magnetic resonance protein structure Alzheimer’s disease filaments Biology (General) QH301-705.5
spellingShingle	tau nuclear magnetic resonance protein structure Alzheimer’s disease filaments Biology (General) QH301-705.5 Kristine Kitoka Rostislav Skrabana Rostislav Skrabana Norbert Gasparik Norbert Gasparik Jozef Hritz Jozef Hritz Kristaps Jaudzems Kristaps Jaudzems NMR Studies of Tau Protein in Tauopathies
description	Tauopathies, including Alzheimer’s disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.
format	article
author	Kristine Kitoka Rostislav Skrabana Rostislav Skrabana Norbert Gasparik Norbert Gasparik Jozef Hritz Jozef Hritz Kristaps Jaudzems Kristaps Jaudzems
author_facet	Kristine Kitoka Rostislav Skrabana Rostislav Skrabana Norbert Gasparik Norbert Gasparik Jozef Hritz Jozef Hritz Kristaps Jaudzems Kristaps Jaudzems
author_sort	Kristine Kitoka
title	NMR Studies of Tau Protein in Tauopathies
title_short	NMR Studies of Tau Protein in Tauopathies
title_full	NMR Studies of Tau Protein in Tauopathies
title_fullStr	NMR Studies of Tau Protein in Tauopathies
title_full_unstemmed	NMR Studies of Tau Protein in Tauopathies
title_sort	nmr studies of tau protein in tauopathies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/217c956f629f478a813ac5043d5e8955
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_version_	1718439108386226176

NMR Studies of Tau Protein in Tauopathies

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