Restarted replication forks are error-prone and cause CAG repeat expansions and contractions.

Restarted replication forks are error-prone and cause CAG repeat expansions and contractions.

Disease-associated trinucleotide repeats form secondary DNA structures that interfere with replication and repair. Replication has been implicated as a mechanism that can cause repeat expansions and contractions. However, because structure-forming repeats are also replication barriers, it has been u...

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Autores principales: Michaela A Gold, Jenna M Whalen, Karine Freon, Zixin Hong, Ismail Iraqui, Sarah A E Lambert, Catherine H Freudenreich
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/217d60e344ba4718b05f2866338cb4b1
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