New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes
Yanxia Chen, Mian Wang Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaCorrespondence: Mian WangDepartment of Endocrinology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, Hebei, 0...
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Dove Medical Press
2021
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oai:doaj.org-article:21845be9bbef4c39812c63be31f6fabd2021-11-30T18:50:36ZNew Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes1177-8881https://doaj.org/article/21845be9bbef4c39812c63be31f6fabd2021-11-01T00:00:00Zhttps://www.dovepress.com/new-insights-of-anti-hyperglycemic-agents-and-traditional-chinese-medi-peer-reviewed-fulltext-article-DDDThttps://doaj.org/toc/1177-8881Yanxia Chen, Mian Wang Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaCorrespondence: Mian WangDepartment of Endocrinology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaEmail wangmian66@sina.comAbstract: Type 2 diabetes mellitus (T2DM) is a widespread metabolic disease characterized by chronic hyperglycemia. Human microbiota, which is regarded as a “hidden organ”, plays an important role in the initiation and development of T2DM. In addition, anti-hyperglycemic agents and traditional Chinese medicine may affect the composition of gut microbiota and consequently improve glucose metabolism. However, the relationship between gut microbiota, T2DM and anti-hyperglycemic agents or traditional Chinese medicine is poorly understood. In this review, we summarized pre-clinical and clinical studies to elucidate the possible underlying mechanism. Some anti-hyperglycemic agents and traditional Chinese medicine may partly exert hypoglycemic effects by altering the gut microbiota composition in ways that reduce metabolic endotoxemia, maintain the integrity of intestinal mucosal barrier, promote the production of short-chain fatty acids (SCFAs), decrease trimethylamine-N-oxide (TMAO) and regulate bile acid metabolism. In conclusion, gut microbiota may provide some new therapeutic targets for treatment of patients with diabetes mellitus.Keywords: gut microbiota, anti-hyperglycemic agents, traditional Chinese medicine, type 2 diabetes mellitusChen YWang MDove Medical Pressarticlegut microbiotaanti-hyperglycemic agentstraditional chinese medicinetype 2 diabetes mellitus.Therapeutics. PharmacologyRM1-950ENDrug Design, Development and Therapy, Vol Volume 15, Pp 4849-4863 (2021) |
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EN |
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gut microbiota anti-hyperglycemic agents traditional chinese medicine type 2 diabetes mellitus. Therapeutics. Pharmacology RM1-950 |
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gut microbiota anti-hyperglycemic agents traditional chinese medicine type 2 diabetes mellitus. Therapeutics. Pharmacology RM1-950 Chen Y Wang M New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
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Yanxia Chen, Mian Wang Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaCorrespondence: Mian WangDepartment of Endocrinology, The Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaEmail wangmian66@sina.comAbstract: Type 2 diabetes mellitus (T2DM) is a widespread metabolic disease characterized by chronic hyperglycemia. Human microbiota, which is regarded as a “hidden organ”, plays an important role in the initiation and development of T2DM. In addition, anti-hyperglycemic agents and traditional Chinese medicine may affect the composition of gut microbiota and consequently improve glucose metabolism. However, the relationship between gut microbiota, T2DM and anti-hyperglycemic agents or traditional Chinese medicine is poorly understood. In this review, we summarized pre-clinical and clinical studies to elucidate the possible underlying mechanism. Some anti-hyperglycemic agents and traditional Chinese medicine may partly exert hypoglycemic effects by altering the gut microbiota composition in ways that reduce metabolic endotoxemia, maintain the integrity of intestinal mucosal barrier, promote the production of short-chain fatty acids (SCFAs), decrease trimethylamine-N-oxide (TMAO) and regulate bile acid metabolism. In conclusion, gut microbiota may provide some new therapeutic targets for treatment of patients with diabetes mellitus.Keywords: gut microbiota, anti-hyperglycemic agents, traditional Chinese medicine, type 2 diabetes mellitus |
| format |
article |
| author |
Chen Y Wang M |
| author_facet |
Chen Y Wang M |
| author_sort |
Chen Y |
| title |
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
| title_short |
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
| title_full |
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
| title_fullStr |
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
| title_full_unstemmed |
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes |
| title_sort |
new insights of anti-hyperglycemic agents and traditional chinese medicine on gut microbiota in type 2 diabetes |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/21845be9bbef4c39812c63be31f6fabd |
| work_keys_str_mv |
AT cheny newinsightsofantihyperglycemicagentsandtraditionalchinesemedicineongutmicrobiotaintype2diabetes AT wangm newinsightsofantihyperglycemicagentsandtraditionalchinesemedicineongutmicrobiotaintype2diabetes |
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