Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jack D. Adderley, Simona John von Freyend, Sarah A. Jackson, Megan J. Bird, Amy L. Burns, Burcu Anar, Tom Metcalf, Jean-Philippe Semblat, Oliver Billker, Danny W. Wilson, Christian Doerig
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2184f8c6d5224440bbad4ee6681c855d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2184f8c6d5224440bbad4ee6681c855d
record_format	dspace
spelling	oai:doaj.org-article:2184f8c6d5224440bbad4ee6681c855d2021-12-02T16:28:07ZAnalysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention10.1038/s41467-020-17829-72041-1723https://doaj.org/article/2184f8c6d5224440bbad4ee6681c855d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17829-7https://doaj.org/toc/2041-1723Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation.Jack D. AdderleySimona John von FreyendSarah A. JacksonMegan J. BirdAmy L. BurnsBurcu AnarTom MetcalfJean-Philippe SemblatOliver BillkerDanny W. WilsonChristian DoerigNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
description	Plasmodium infection activates signaling pathways in a-nucleated erythrocytes. Here, Adderley et al. use a comprehensive antibody microarray to show that infection extensively modulates host cell signalling and that the host receptor tyrosine kinase c-MET supports Plasmodium falciparum proliferation.
format	article
author	Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig
author_facet	Jack D. Adderley Simona John von Freyend Sarah A. Jackson Megan J. Bird Amy L. Burns Burcu Anar Tom Metcalf Jean-Philippe Semblat Oliver Billker Danny W. Wilson Christian Doerig
author_sort	Jack D. Adderley
title	Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
title_short	Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
title_full	Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
title_fullStr	Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
title_full_unstemmed	Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
title_sort	analysis of erythrocyte signalling pathways during plasmodium falciparum infection identifies targets for host-directed antimalarial intervention
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2184f8c6d5224440bbad4ee6681c855d
work_keys_str_mv	AT jackdadderley analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT simonajohnvonfreyend analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT sarahajackson analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT meganjbird analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT amylburns analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT burcuanar analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT tommetcalf analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT jeanphilippesemblat analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT oliverbillker analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT dannywwilson analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention AT christiandoerig analysisoferythrocytesignallingpathwaysduringplasmodiumfalciparuminfectionidentifiestargetsforhostdirectedantimalarialintervention
_version_	1718383917510164480

Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention

Ejemplares similares