Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing.
<h4>Background</h4>The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the ca...
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oai:doaj.org-article:2185b812558d4a94899bd283296bdde82021-11-18T06:48:49ZIncidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing.1932-620310.1371/journal.pone.0020294https://doaj.org/article/2185b812558d4a94899bd283296bdde82011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21826194/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases.<h4>Methodology/principal findings</h4>From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000).<h4>Conclusions/significance</h4>The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas.Françoise DucimetièreAntoine LurkinDominique Ranchère-VinceAnne-Valérie DecouvelaereMichel Péoc'hLuc IstierPhilippe ChalabreysseChristine MullerLaurent AlbertiPierre-Paul BringuierJean-Yves ScoazecAnne-Marie SchottChristophe BergeronDominic CellierJean-Yves BlayIsabelle Ray-CoquardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e20294 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Françoise Ducimetière Antoine Lurkin Dominique Ranchère-Vince Anne-Valérie Decouvelaere Michel Péoc'h Luc Istier Philippe Chalabreysse Christine Muller Laurent Alberti Pierre-Paul Bringuier Jean-Yves Scoazec Anne-Marie Schott Christophe Bergeron Dominic Cellier Jean-Yves Blay Isabelle Ray-Coquard Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| description |
<h4>Background</h4>The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases.<h4>Methodology/principal findings</h4>From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000).<h4>Conclusions/significance</h4>The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas. |
| format |
article |
| author |
Françoise Ducimetière Antoine Lurkin Dominique Ranchère-Vince Anne-Valérie Decouvelaere Michel Péoc'h Luc Istier Philippe Chalabreysse Christine Muller Laurent Alberti Pierre-Paul Bringuier Jean-Yves Scoazec Anne-Marie Schott Christophe Bergeron Dominic Cellier Jean-Yves Blay Isabelle Ray-Coquard |
| author_facet |
Françoise Ducimetière Antoine Lurkin Dominique Ranchère-Vince Anne-Valérie Decouvelaere Michel Péoc'h Luc Istier Philippe Chalabreysse Christine Muller Laurent Alberti Pierre-Paul Bringuier Jean-Yves Scoazec Anne-Marie Schott Christophe Bergeron Dominic Cellier Jean-Yves Blay Isabelle Ray-Coquard |
| author_sort |
Françoise Ducimetière |
| title |
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| title_short |
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| title_full |
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| title_fullStr |
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| title_full_unstemmed |
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| title_sort |
incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/2185b812558d4a94899bd283296bdde8 |
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