Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion

In order to elucidate how callyspongiolide, a potent cytotoxic marine natural product, kills human lung cancer cells, Ha and Park employed TS-FITGE technique, a label-free target identification method with thermal stability-shift-based fluorescence difference in 2-D gel electrophoresis, allowing the...

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Autores principales:	Jaeyoung Ha, Seung Bum Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/21861e7f52244f70ac8f9eb09ea4dba8
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spelling	oai:doaj.org-article:21861e7f52244f70ac8f9eb09ea4dba82021-12-02T17:26:48ZCallyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion10.1038/s42003-021-02643-82399-3642https://doaj.org/article/21861e7f52244f70ac8f9eb09ea4dba82021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02643-8https://doaj.org/toc/2399-3642In order to elucidate how callyspongiolide, a potent cytotoxic marine natural product, kills human lung cancer cells, Ha and Park employed TS-FITGE technique, a label-free target identification method with thermal stability-shift-based fluorescence difference in 2-D gel electrophoresis, allowing them to observe protein-spot separation upon treatment in increasing temperatures. They found that callyspongiolide induces lysosomal dysfunction followed by mitochondrial dysfunction as well as iron depletion, which sheds light on the mechanism of action of callyspongiolide.Jaeyoung HaSeung Bum ParkNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jaeyoung Ha Seung Bum Park Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
description	In order to elucidate how callyspongiolide, a potent cytotoxic marine natural product, kills human lung cancer cells, Ha and Park employed TS-FITGE technique, a label-free target identification method with thermal stability-shift-based fluorescence difference in 2-D gel electrophoresis, allowing them to observe protein-spot separation upon treatment in increasing temperatures. They found that callyspongiolide induces lysosomal dysfunction followed by mitochondrial dysfunction as well as iron depletion, which sheds light on the mechanism of action of callyspongiolide.
format	article
author	Jaeyoung Ha Seung Bum Park
author_facet	Jaeyoung Ha Seung Bum Park
author_sort	Jaeyoung Ha
title	Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
title_short	Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
title_full	Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
title_fullStr	Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
title_full_unstemmed	Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
title_sort	callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21861e7f52244f70ac8f9eb09ea4dba8
work_keys_str_mv	AT jaeyoungha callyspongiolidekillscellsbyinducingmitochondrialdysfunctionviacellularirondepletion AT seungbumpark callyspongiolidekillscellsbyinducingmitochondrialdysfunctionviacellularirondepletion
_version_	1718380778823352320

Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion

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