Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study

Abstract Patients with end-stage kidney disease (ESKD) have been reported to have an increased risk of cancer. However, the epidemiological characteristics of cancer in ESKD patients remain unclear. Therefore, this study aimed to investigate the epidemiological characteristics of cancer in ESKD pati...

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Autores principales:	Min-Jeong Lee, Eunyoung Lee, Bumhee Park, Inwhee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/218e3f28141341fa892a0aa52cd85313
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spelling	oai:doaj.org-article:218e3f28141341fa892a0aa52cd853132021-12-02T14:21:51ZEpidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study10.1038/s41598-021-83164-62045-2322https://doaj.org/article/218e3f28141341fa892a0aa52cd853132021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83164-6https://doaj.org/toc/2045-2322Abstract Patients with end-stage kidney disease (ESKD) have been reported to have an increased risk of cancer. However, the epidemiological characteristics of cancer in ESKD patients remain unclear. Therefore, this study aimed to investigate the epidemiological characteristics of cancer in ESKD patients and the differences based on the renal replacement therapy provided. Data on ESKD patients were obtained from the South Korean nationwide cohort Health Insurance Review and Assessment Service database. This study included 58,831 eligible patients of the total 813,907 patients diagnosed with ESKD between January 1, 2007 and December 31, 2017. Of the 58,831 ESKD patients, 3292 (5.6%) were newly diagnosed with cancer. The average duration between the diagnosis of ESKD and cancer was 3.3 ± 1.9 years (mean ± standard deviation), with no differences between hemodialysis, peritoneal dialysis, and kidney transplant groups. The most commonly observed cancer sites in ESKD patients were the colorectum, lung, and liver. The incidence of cancer increased progressively among patients undergoing kidney transplant, peritoneal dialysis, and hemodialysis in that order. Hemodialysis patients were found to have an increased risk of digestive tract cancer compared with kidney transplant patients (adjusted hazard ratio = 1.9; 95% confidence interval: 1.31–2.81; P < 0.001). The study findings may be a useful reference for cancer-screening guidelines.Min-Jeong LeeEunyoung LeeBumhee ParkInwhee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min-Jeong Lee Eunyoung Lee Bumhee Park Inwhee Park Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
description	Abstract Patients with end-stage kidney disease (ESKD) have been reported to have an increased risk of cancer. However, the epidemiological characteristics of cancer in ESKD patients remain unclear. Therefore, this study aimed to investigate the epidemiological characteristics of cancer in ESKD patients and the differences based on the renal replacement therapy provided. Data on ESKD patients were obtained from the South Korean nationwide cohort Health Insurance Review and Assessment Service database. This study included 58,831 eligible patients of the total 813,907 patients diagnosed with ESKD between January 1, 2007 and December 31, 2017. Of the 58,831 ESKD patients, 3292 (5.6%) were newly diagnosed with cancer. The average duration between the diagnosis of ESKD and cancer was 3.3 ± 1.9 years (mean ± standard deviation), with no differences between hemodialysis, peritoneal dialysis, and kidney transplant groups. The most commonly observed cancer sites in ESKD patients were the colorectum, lung, and liver. The incidence of cancer increased progressively among patients undergoing kidney transplant, peritoneal dialysis, and hemodialysis in that order. Hemodialysis patients were found to have an increased risk of digestive tract cancer compared with kidney transplant patients (adjusted hazard ratio = 1.9; 95% confidence interval: 1.31–2.81; P < 0.001). The study findings may be a useful reference for cancer-screening guidelines.
format	article
author	Min-Jeong Lee Eunyoung Lee Bumhee Park Inwhee Park
author_facet	Min-Jeong Lee Eunyoung Lee Bumhee Park Inwhee Park
author_sort	Min-Jeong Lee
title	Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
title_short	Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
title_full	Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
title_fullStr	Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
title_full_unstemmed	Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study
title_sort	epidemiological characteristics of cancers in patients with end-stage kidney disease: a korean nationwide study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/218e3f28141341fa892a0aa52cd85313
work_keys_str_mv	AT minjeonglee epidemiologicalcharacteristicsofcancersinpatientswithendstagekidneydiseaseakoreannationwidestudy AT eunyounglee epidemiologicalcharacteristicsofcancersinpatientswithendstagekidneydiseaseakoreannationwidestudy AT bumheepark epidemiologicalcharacteristicsofcancersinpatientswithendstagekidneydiseaseakoreannationwidestudy AT inwheepark epidemiologicalcharacteristicsofcancersinpatientswithendstagekidneydiseaseakoreannationwidestudy
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Epidemiological characteristics of cancers in patients with end-stage kidney disease: a Korean nationwide study

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