The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors

Abstract It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n ~ 15...

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Autores principales:	Carol A. Wang, John R. Attia, Stephen J. Lye, Wendy H. Oddy, Lawrence Beilin, Trevor A. Mori, Claire Meyerkort, Craig E. Pennell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/218f5eac787847dba1b35fbd117a538f
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spelling	oai:doaj.org-article:218f5eac787847dba1b35fbd117a538f2021-12-02T17:55:13ZThe interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors10.1038/s41598-021-94206-42045-2322https://doaj.org/article/218f5eac787847dba1b35fbd117a538f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94206-4https://doaj.org/toc/2045-2322Abstract It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.Carol A. WangJohn R. AttiaStephen J. LyeWendy H. OddyLawrence BeilinTrevor A. MoriClaire MeyerkortCraig E. PennellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carol A. Wang John R. Attia Stephen J. Lye Wendy H. Oddy Lawrence Beilin Trevor A. Mori Claire Meyerkort Craig E. Pennell The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
description	Abstract It is well established that genetics, environment, and interplay between them play a crucial role in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and the interaction between them, on optimal adult health. As part of a large international consortium (n ~ 154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based on the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was particularly associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.
format	article
author	Carol A. Wang John R. Attia Stephen J. Lye Wendy H. Oddy Lawrence Beilin Trevor A. Mori Claire Meyerkort Craig E. Pennell
author_facet	Carol A. Wang John R. Attia Stephen J. Lye Wendy H. Oddy Lawrence Beilin Trevor A. Mori Claire Meyerkort Craig E. Pennell
author_sort	Carol A. Wang
title	The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
title_short	The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
title_full	The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
title_fullStr	The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
title_full_unstemmed	The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
title_sort	interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/218f5eac787847dba1b35fbd117a538f
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The interactions between genetics and early childhood nutrition influence adult cardiometabolic risk factors

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