EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.

An amplifying role for oral epithelial cells (ECs) in Epstein-Barr Virus (EBV) infection has been postulated to explain oral viral shedding. However, while lytic or latent EBV infections of oro/nasopharyngeal ECs are commonly detected under pathological conditions, detection of EBV-infected ECs in h...

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Autores principales:	Séverine Vincent-Bugnas, Sébastien Vitale, Caroline C Mouline, Wafa Khaali, Yves Charbit, Patrick Mahler, Isabelle Prêcheur, Paul Hofman, Janet L Maryanski, Alain Doglio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21919d7950b84c93b332b6ecac733d8b
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spelling	oai:doaj.org-article:21919d7950b84c93b332b6ecac733d8b2021-11-18T08:41:12ZEBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.1932-620310.1371/journal.pone.0080336https://doaj.org/article/21919d7950b84c93b332b6ecac733d8b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24367478/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203An amplifying role for oral epithelial cells (ECs) in Epstein-Barr Virus (EBV) infection has been postulated to explain oral viral shedding. However, while lytic or latent EBV infections of oro/nasopharyngeal ECs are commonly detected under pathological conditions, detection of EBV-infected ECs in healthy conditions is very rare. In this study, a simple non-surgical tissue sampling procedure was used to investigate EBV infection in the periodontal epithelium that surrounds and attaches teeth to the gingiva. Surprisingly, we observed that the gingival ECs of the periodontium (pECs) are commonly infected with EBV and may serve as an important oral reservoir of latently EBV-infected cells. We also found that the basal level of epithelial EBV-infection is significantly increased in chronic periodontitis, a common inflammatory disease that undermines the integrity of tooth-supporting tissues. Moreover, the level of EBV infection was found to correlate with disease severity. In inflamed tissues, EBV-infected pECs appear to be prone to apoptosis and to produce larger amounts of CCL20, a pivotal inflammatory chemokine that controls tissue infiltration by immune cells. Our discovery that the periodontal epithelium is a major site of latent EBV infection sheds a new light on EBV persistence in healthy carriers and on the role of this ubiquitous virus in periodontitis. Moreover, the identification of this easily accessible site of latent infection may encourage new approaches to investigate and monitor other EBV-associated disorders.Séverine Vincent-BugnasSébastien VitaleCaroline C MoulineWafa KhaaliYves CharbitPatrick MahlerIsabelle PrêcheurPaul HofmanJanet L MaryanskiAlain DoglioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80336 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Séverine Vincent-Bugnas Sébastien Vitale Caroline C Mouline Wafa Khaali Yves Charbit Patrick Mahler Isabelle Prêcheur Paul Hofman Janet L Maryanski Alain Doglio EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
description	An amplifying role for oral epithelial cells (ECs) in Epstein-Barr Virus (EBV) infection has been postulated to explain oral viral shedding. However, while lytic or latent EBV infections of oro/nasopharyngeal ECs are commonly detected under pathological conditions, detection of EBV-infected ECs in healthy conditions is very rare. In this study, a simple non-surgical tissue sampling procedure was used to investigate EBV infection in the periodontal epithelium that surrounds and attaches teeth to the gingiva. Surprisingly, we observed that the gingival ECs of the periodontium (pECs) are commonly infected with EBV and may serve as an important oral reservoir of latently EBV-infected cells. We also found that the basal level of epithelial EBV-infection is significantly increased in chronic periodontitis, a common inflammatory disease that undermines the integrity of tooth-supporting tissues. Moreover, the level of EBV infection was found to correlate with disease severity. In inflamed tissues, EBV-infected pECs appear to be prone to apoptosis and to produce larger amounts of CCL20, a pivotal inflammatory chemokine that controls tissue infiltration by immune cells. Our discovery that the periodontal epithelium is a major site of latent EBV infection sheds a new light on EBV persistence in healthy carriers and on the role of this ubiquitous virus in periodontitis. Moreover, the identification of this easily accessible site of latent infection may encourage new approaches to investigate and monitor other EBV-associated disorders.
format	article
author	Séverine Vincent-Bugnas Sébastien Vitale Caroline C Mouline Wafa Khaali Yves Charbit Patrick Mahler Isabelle Prêcheur Paul Hofman Janet L Maryanski Alain Doglio
author_facet	Séverine Vincent-Bugnas Sébastien Vitale Caroline C Mouline Wafa Khaali Yves Charbit Patrick Mahler Isabelle Prêcheur Paul Hofman Janet L Maryanski Alain Doglio
author_sort	Séverine Vincent-Bugnas
title	EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
title_short	EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
title_full	EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
title_fullStr	EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
title_full_unstemmed	EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
title_sort	ebv infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/21919d7950b84c93b332b6ecac733d8b
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EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.

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