A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide. High propensity of the hTTR fragment to form pathogenic protein aggregates implicates the serine protease i...

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Autores principales:	Daniele Peterle, Giulia Pontarollo, Stefano Spada, Paola Brun, Luana Palazzi, Alexej V. Sokolov, Barbara Spolaore, Patrizia Polverino de Laureto, Vadim B. Vasilyev, Ignazio Castagliuolo, Vincenzo De Filippis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2199dcaae147423ba84acbd941b4fee7
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spelling	oai:doaj.org-article:2199dcaae147423ba84acbd941b4fee72021-12-02T12:33:13ZA serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment10.1038/s42003-020-01493-02399-3642https://doaj.org/article/2199dcaae147423ba84acbd941b4fee72020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01493-0https://doaj.org/toc/2399-3642Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide. High propensity of the hTTR fragment to form pathogenic protein aggregates implicates the serine protease in the pathogenesis of acquired senile systemic amyloidosis.Daniele PeterleGiulia PontarolloStefano SpadaPaola BrunLuana PalazziAlexej V. SokolovBarbara SpolaorePatrizia Polverino de LauretoVadim B. VasilyevIgnazio CastagliuoloVincenzo De FilippisNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniele Peterle Giulia Pontarollo Stefano Spada Paola Brun Luana Palazzi Alexej V. Sokolov Barbara Spolaore Patrizia Polverino de Laureto Vadim B. Vasilyev Ignazio Castagliuolo Vincenzo De Filippis A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
description	Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide. High propensity of the hTTR fragment to form pathogenic protein aggregates implicates the serine protease in the pathogenesis of acquired senile systemic amyloidosis.
format	article
author	Daniele Peterle Giulia Pontarollo Stefano Spada Paola Brun Luana Palazzi Alexej V. Sokolov Barbara Spolaore Patrizia Polverino de Laureto Vadim B. Vasilyev Ignazio Castagliuolo Vincenzo De Filippis
author_facet	Daniele Peterle Giulia Pontarollo Stefano Spada Paola Brun Luana Palazzi Alexej V. Sokolov Barbara Spolaore Patrizia Polverino de Laureto Vadim B. Vasilyev Ignazio Castagliuolo Vincenzo De Filippis
author_sort	Daniele Peterle
title	A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
title_short	A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
title_full	A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
title_fullStr	A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
title_full_unstemmed	A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
title_sort	serine protease secreted from bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2199dcaae147423ba84acbd941b4fee7
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A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

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