Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas

Abstract Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the...

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Autores principales:	Shunsuke Nakae, Masanobu Kumon, Kazuhiro Murayama, Shigeo Ohba, Hikaru Sasaki, Joji Inamasu, Kiyonori Kuwahara, Seiji Yamada, Masato Abe, Yuichi Hirose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/219a878083ef42a8b595b363d7eb2276
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spelling	oai:doaj.org-article:219a878083ef42a8b595b363d7eb22762021-12-02T18:03:21ZAssociation of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas10.1038/s41598-021-86487-62045-2322https://doaj.org/article/219a878083ef42a8b595b363d7eb22762021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86487-6https://doaj.org/toc/2045-2322Abstract Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epileptogenesis in gliomas, and specific metabolites might be indicators of preoperative seizures in gliomas. We retrospectively investigated patient information (gender, age at diagnosis of tumor, their survival time) and tumor information (location, histology, genetic features, and metabolites according to MRS) in patients with gliomas. The data were correlated with the incidence of seizure and analyzed statistically. Of 146 adult supratentorial gliomas, isocitrate dehydrogenase (IDH) mutant tumors significantly indicated higher incidence of preoperative seizures than IDH wild-type gliomas. However, MRS study indicated that glutamate concentration in IDH wild-type gliomas was higher than that in IDH mutant gliomas. Glutamate was not associated with high frequency of preoperative seizures in patients with gliomas. Instead, increased total N-acetyl-l-aspartate (tNAA) was significantly associated with them. Moreover, multivariable analysis indicated that increased level of tNAA was an independent predictor of preoperative seizures. According to MRS analysis, tNAA, rather than glutamate, might be a useful to detect preoperative seizures in patient with supratentorial gliomas.Shunsuke NakaeMasanobu KumonKazuhiro MurayamaShigeo OhbaHikaru SasakiJoji InamasuKiyonori KuwaharaSeiji YamadaMasato AbeYuichi HiroseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shunsuke Nakae Masanobu Kumon Kazuhiro Murayama Shigeo Ohba Hikaru Sasaki Joji Inamasu Kiyonori Kuwahara Seiji Yamada Masato Abe Yuichi Hirose Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
description	Abstract Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epileptogenesis in gliomas, and specific metabolites might be indicators of preoperative seizures in gliomas. We retrospectively investigated patient information (gender, age at diagnosis of tumor, their survival time) and tumor information (location, histology, genetic features, and metabolites according to MRS) in patients with gliomas. The data were correlated with the incidence of seizure and analyzed statistically. Of 146 adult supratentorial gliomas, isocitrate dehydrogenase (IDH) mutant tumors significantly indicated higher incidence of preoperative seizures than IDH wild-type gliomas. However, MRS study indicated that glutamate concentration in IDH wild-type gliomas was higher than that in IDH mutant gliomas. Glutamate was not associated with high frequency of preoperative seizures in patients with gliomas. Instead, increased total N-acetyl-l-aspartate (tNAA) was significantly associated with them. Moreover, multivariable analysis indicated that increased level of tNAA was an independent predictor of preoperative seizures. According to MRS analysis, tNAA, rather than glutamate, might be a useful to detect preoperative seizures in patient with supratentorial gliomas.
format	article
author	Shunsuke Nakae Masanobu Kumon Kazuhiro Murayama Shigeo Ohba Hikaru Sasaki Joji Inamasu Kiyonori Kuwahara Seiji Yamada Masato Abe Yuichi Hirose
author_facet	Shunsuke Nakae Masanobu Kumon Kazuhiro Murayama Shigeo Ohba Hikaru Sasaki Joji Inamasu Kiyonori Kuwahara Seiji Yamada Masato Abe Yuichi Hirose
author_sort	Shunsuke Nakae
title	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
title_short	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
title_full	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
title_fullStr	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
title_full_unstemmed	Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
title_sort	association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/219a878083ef42a8b595b363d7eb2276
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Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas

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