Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis

Abstract Background Non-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. Methods This was a retrospective multicenter study of MHD patients...

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Autores principales:	Denggui Luo, Yueming Luo, Yanhong Zou, Yuanzhao Xu, Bo Fu, Dong Yang, Jun Yang, Cai Xu, Shuyi Ling, Shunmin Li, Airong Qi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Non-LDL-C Cardio-cerebrovascular risk Maintenance hemodialysis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/219adba0f7cb4230a40d3af7019c4ca0
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spelling	oai:doaj.org-article:219adba0f7cb4230a40d3af7019c4ca02021-11-14T12:39:42ZNon-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis10.1186/s12944-021-01546-11476-511Xhttps://doaj.org/article/219adba0f7cb4230a40d3af7019c4ca02021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01546-1https://doaj.org/toc/1476-511XAbstract Background Non-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. Methods This was a retrospective multicenter study of MHD patients treated at 10 dialysis centers in Guangdong Province from July 1, 2016, to April 1, 2017. Laboratory test data were collected and CVD complications and outcomes recorded. Results In total, 1288 eligible patients were included in this study; the non-HDL-C interquartile range was 2.76 (2.24–3.45) mmol/L. Over a median follow-up time of 24 months, 141 patients developed CVD. The non-HDL-C level was a principal risk factor for such events (P < 0.05; 95% confidence interval 0.800–0.842). The maximum Youden index was 0.549 and the best cutoff > 3.39 mmol/L. Conclusion Higher baseline non-HDL-C levels may increase the CVD risk in MHD patients. Thus, non-HDL-C effectively predicts CVD.Denggui LuoYueming LuoYanhong ZouYuanzhao XuBo FuDong YangJun YangCai XuShuyi LingShunmin LiAirong QiBMCarticleNon-LDL-CCardio-cerebrovascular riskMaintenance hemodialysisNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-LDL-C Cardio-cerebrovascular risk Maintenance hemodialysis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Non-LDL-C Cardio-cerebrovascular risk Maintenance hemodialysis Nutritional diseases. Deficiency diseases RC620-627 Denggui Luo Yueming Luo Yanhong Zou Yuanzhao Xu Bo Fu Dong Yang Jun Yang Cai Xu Shuyi Ling Shunmin Li Airong Qi Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
description	Abstract Background Non-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. Methods This was a retrospective multicenter study of MHD patients treated at 10 dialysis centers in Guangdong Province from July 1, 2016, to April 1, 2017. Laboratory test data were collected and CVD complications and outcomes recorded. Results In total, 1288 eligible patients were included in this study; the non-HDL-C interquartile range was 2.76 (2.24–3.45) mmol/L. Over a median follow-up time of 24 months, 141 patients developed CVD. The non-HDL-C level was a principal risk factor for such events (P < 0.05; 95% confidence interval 0.800–0.842). The maximum Youden index was 0.549 and the best cutoff > 3.39 mmol/L. Conclusion Higher baseline non-HDL-C levels may increase the CVD risk in MHD patients. Thus, non-HDL-C effectively predicts CVD.
format	article
author	Denggui Luo Yueming Luo Yanhong Zou Yuanzhao Xu Bo Fu Dong Yang Jun Yang Cai Xu Shuyi Ling Shunmin Li Airong Qi
author_facet	Denggui Luo Yueming Luo Yanhong Zou Yuanzhao Xu Bo Fu Dong Yang Jun Yang Cai Xu Shuyi Ling Shunmin Li Airong Qi
author_sort	Denggui Luo
title	Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
title_short	Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
title_full	Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
title_fullStr	Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
title_full_unstemmed	Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
title_sort	non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/219adba0f7cb4230a40d3af7019c4ca0
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Non-high-density lipoprotein cholesterol may predict the cardio-cerebrovascular risk in patients on maintenance hemodialysis

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