Modulation of Immune Components on Stem Cell and Dormancy in Cancer

Cancer stem cells (CSCs) refer to a certain subpopulation within the tumor entity that is characterized by restricted cellular proliferation and multipotent differentiation potency. The existence of CSCs has been proven to contribute to the heterogeneity of malignancies, accounting for intensified t...

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Autores principales:	Xiaofan Jiang, Lu Liang, Guanglei Chen, Caigang Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer stem cell dormancy immune cell intercellular communication CSC niche Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/219cc7b6e41444dca2b94bbe89ff81e6
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spelling	oai:doaj.org-article:219cc7b6e41444dca2b94bbe89ff81e62021-11-25T17:07:38ZModulation of Immune Components on Stem Cell and Dormancy in Cancer10.3390/cells101128262073-4409https://doaj.org/article/219cc7b6e41444dca2b94bbe89ff81e62021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2826https://doaj.org/toc/2073-4409Cancer stem cells (CSCs) refer to a certain subpopulation within the tumor entity that is characterized by restricted cellular proliferation and multipotent differentiation potency. The existence of CSCs has been proven to contribute to the heterogeneity of malignancies, accounting for intensified tumorigenesis, treatment resistance, and metastatic spread. Dormancy was proposed as a reversible state of cancer cells that are temporarily arrested in the cell cycle, possessing several hallmarks that facilitate their survival within a devastating niche. This transient period is evoked to enter an actively proliferating state by multiple regulatory alterations, and one of the most significant and complex factors comes from local and systemic inflammatory reactions and immune components. Although CSCs and dormant cancer cells share several similarities, the clear relationship between these two concepts remains unclear. Thus, the detailed mechanism of immune cells interacting with CSCs and dormant cancer cells also warrants elucidation for prevention of cancer relapse and metastasis. In this review, we summarize recent findings and prospective studies on CSCs and cancer dormancy to conclude the relationship between these two concepts. Furthermore, we aim to outline the mechanism of immune components in interfering with CSCs and dormant cancer cells to provide a theoretical basis for the prevention of relapse and metastasis.Xiaofan JiangLu LiangGuanglei ChenCaigang LiuMDPI AGarticlecancer stem celldormancyimmune cellintercellular communicationCSC nicheBiology (General)QH301-705.5ENCells, Vol 10, Iss 2826, p 2826 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer stem cell dormancy immune cell intercellular communication CSC niche Biology (General) QH301-705.5
spellingShingle	cancer stem cell dormancy immune cell intercellular communication CSC niche Biology (General) QH301-705.5 Xiaofan Jiang Lu Liang Guanglei Chen Caigang Liu Modulation of Immune Components on Stem Cell and Dormancy in Cancer
description	Cancer stem cells (CSCs) refer to a certain subpopulation within the tumor entity that is characterized by restricted cellular proliferation and multipotent differentiation potency. The existence of CSCs has been proven to contribute to the heterogeneity of malignancies, accounting for intensified tumorigenesis, treatment resistance, and metastatic spread. Dormancy was proposed as a reversible state of cancer cells that are temporarily arrested in the cell cycle, possessing several hallmarks that facilitate their survival within a devastating niche. This transient period is evoked to enter an actively proliferating state by multiple regulatory alterations, and one of the most significant and complex factors comes from local and systemic inflammatory reactions and immune components. Although CSCs and dormant cancer cells share several similarities, the clear relationship between these two concepts remains unclear. Thus, the detailed mechanism of immune cells interacting with CSCs and dormant cancer cells also warrants elucidation for prevention of cancer relapse and metastasis. In this review, we summarize recent findings and prospective studies on CSCs and cancer dormancy to conclude the relationship between these two concepts. Furthermore, we aim to outline the mechanism of immune components in interfering with CSCs and dormant cancer cells to provide a theoretical basis for the prevention of relapse and metastasis.
format	article
author	Xiaofan Jiang Lu Liang Guanglei Chen Caigang Liu
author_facet	Xiaofan Jiang Lu Liang Guanglei Chen Caigang Liu
author_sort	Xiaofan Jiang
title	Modulation of Immune Components on Stem Cell and Dormancy in Cancer
title_short	Modulation of Immune Components on Stem Cell and Dormancy in Cancer
title_full	Modulation of Immune Components on Stem Cell and Dormancy in Cancer
title_fullStr	Modulation of Immune Components on Stem Cell and Dormancy in Cancer
title_full_unstemmed	Modulation of Immune Components on Stem Cell and Dormancy in Cancer
title_sort	modulation of immune components on stem cell and dormancy in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/219cc7b6e41444dca2b94bbe89ff81e6
work_keys_str_mv	AT xiaofanjiang modulationofimmunecomponentsonstemcellanddormancyincancer AT luliang modulationofimmunecomponentsonstemcellanddormancyincancer AT guangleichen modulationofimmunecomponentsonstemcellanddormancyincancer AT caigangliu modulationofimmunecomponentsonstemcellanddormancyincancer
_version_	1718412700261810176

Modulation of Immune Components on Stem Cell and Dormancy in Cancer

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