Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study

Abstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudan...

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Autores principales:	Elfatih A. Hasabo, Fatima A. Ayyad, Sara A. M. Alam Eldeen, Malaz K. Noureldaim, Tibyan A. Abdallah, Yousra T. Ahmed, Safaa Badi, Waleed K. Khalid, Hind A. Mirghani, Yossra A. Mohammed, Lubaba A. Alkhider, Saada A. Hamad, Amna M. Tagelseed, Ethar H. A. Elsheikh, Noon H. Khalid, Samia A. Mohammed, Sara O. Elmobark, Ola O. Ali, Duaa A. Mohammed Ali, Mohamed S. Muneer, Heitham Awadalla, Elfatih M. Malik
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 Clinical manifestations In-hospital outcomes Complications Sudan Severity Arctic medicine. Tropical medicine RC955-962
Acceso en línea:	https://doaj.org/article/219d7c2b33694239b83304b1ed0eaca7
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spelling	oai:doaj.org-article:219d7c2b33694239b83304b1ed0eaca72021-11-21T12:40:39ZClinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study10.1186/s41182-021-00382-41349-4147https://doaj.org/article/219d7c2b33694239b83304b1ed0eaca72021-11-01T00:00:00Zhttps://doi.org/10.1186/s41182-021-00382-4https://doaj.org/toc/1349-4147Abstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19. Methods This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients’ records using an extraction form designed for this study. Results Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359–760), D-dimer had a median of 3.3 (1.2–16. 6), and 53/105 (50.5%) had low albumin. Conclusions Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19.Elfatih A. HasaboFatima A. AyyadSara A. M. Alam EldeenMalaz K. NoureldaimTibyan A. AbdallahYousra T. AhmedSafaa BadiWaleed K. KhalidHind A. MirghaniYossra A. MohammedLubaba A. AlkhiderSaada A. HamadAmna M. TagelseedEthar H. A. ElsheikhNoon H. KhalidSamia A. MohammedSara O. ElmobarkOla O. AliDuaa A. Mohammed AliMohamed S. MuneerHeitham AwadallaElfatih M. MalikBMCarticleCOVID-19Clinical manifestationsIn-hospital outcomesComplicationsSudanSeverityArctic medicine. Tropical medicineRC955-962ENTropical Medicine and Health, Vol 49, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Clinical manifestations In-hospital outcomes Complications Sudan Severity Arctic medicine. Tropical medicine RC955-962
spellingShingle	COVID-19 Clinical manifestations In-hospital outcomes Complications Sudan Severity Arctic medicine. Tropical medicine RC955-962 Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
description	Abstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19. Methods This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients’ records using an extraction form designed for this study. Results Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359–760), D-dimer had a median of 3.3 (1.2–16. 6), and 53/105 (50.5%) had low albumin. Conclusions Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19.
format	article
author	Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik
author_facet	Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik
author_sort	Elfatih A. Hasabo
title	Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
title_short	Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
title_full	Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
title_fullStr	Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
title_full_unstemmed	Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
title_sort	clinical manifestations, complications, and outcomes of patients with covid-19 in sudan: a multicenter observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/219d7c2b33694239b83304b1ed0eaca7
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Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study

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