Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

The pathogenicity ofFrancisellaspecies largely depends on their escape from phagosomes in macrophages, mediated by a type VI secretion system (T6SS). Here, the authors show dynamics of T6SS assembly and disassembly and identify the genes essential for phagosome escape and pathogenicity in mice.

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Autores principales:	Maj Brodmann, Roland F. Dreier, Petr Broz, Marek Basler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/219e24a7c4a6467a9aed759dbf29e440
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spelling	oai:doaj.org-article:219e24a7c4a6467a9aed759dbf29e4402021-12-02T14:42:26ZFrancisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape10.1038/ncomms158532041-1723https://doaj.org/article/219e24a7c4a6467a9aed759dbf29e4402017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15853https://doaj.org/toc/2041-1723The pathogenicity ofFrancisellaspecies largely depends on their escape from phagosomes in macrophages, mediated by a type VI secretion system (T6SS). Here, the authors show dynamics of T6SS assembly and disassembly and identify the genes essential for phagosome escape and pathogenicity in mice.Maj BrodmannRoland F. DreierPetr BrozMarek BaslerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maj Brodmann Roland F. Dreier Petr Broz Marek Basler Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
description	The pathogenicity ofFrancisellaspecies largely depends on their escape from phagosomes in macrophages, mediated by a type VI secretion system (T6SS). Here, the authors show dynamics of T6SS assembly and disassembly and identify the genes essential for phagosome escape and pathogenicity in mice.
format	article
author	Maj Brodmann Roland F. Dreier Petr Broz Marek Basler
author_facet	Maj Brodmann Roland F. Dreier Petr Broz Marek Basler
author_sort	Maj Brodmann
title	Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
title_short	Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
title_full	Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
title_fullStr	Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
title_full_unstemmed	Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
title_sort	francisella requires dynamic type vi secretion system and clpb to deliver effectors for phagosomal escape
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/219e24a7c4a6467a9aed759dbf29e440
work_keys_str_mv	AT majbrodmann francisellarequiresdynamictypevisecretionsystemandclpbtodelivereffectorsforphagosomalescape AT rolandfdreier francisellarequiresdynamictypevisecretionsystemandclpbtodelivereffectorsforphagosomalescape AT petrbroz francisellarequiresdynamictypevisecretionsystemandclpbtodelivereffectorsforphagosomalescape AT marekbasler francisellarequiresdynamictypevisecretionsystemandclpbtodelivereffectorsforphagosomalescape
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Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

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