LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic a...
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Nature Portfolio
2020
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oai:doaj.org-article:219e2bb5225f43dcb77d228c096f4de82021-12-02T17:33:12ZLSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development10.1038/s41467-020-16017-x2041-1723https://doaj.org/article/219e2bb5225f43dcb77d228c096f4de82020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16017-xhttps://doaj.org/toc/2041-1723How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid.Nicholas K. VinckierNisha A. PatelRyan J. GeuszAllen WangJinzhao WangIleana MattaAustin R. HarringtonMatthew WorthamNichole WettonJianxun WangUlupi S. JhalaMichael G. RosenfeldChristopher W. BennerHung-Ping ShihMaike SanderNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nicholas K. Vinckier Nisha A. Patel Ryan J. Geusz Allen Wang Jinzhao Wang Ileana Matta Austin R. Harrington Matthew Wortham Nichole Wetton Jianxun Wang Ulupi S. Jhala Michael G. Rosenfeld Christopher W. Benner Hung-Ping Shih Maike Sander LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| description |
How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid. |
| format |
article |
| author |
Nicholas K. Vinckier Nisha A. Patel Ryan J. Geusz Allen Wang Jinzhao Wang Ileana Matta Austin R. Harrington Matthew Wortham Nichole Wetton Jianxun Wang Ulupi S. Jhala Michael G. Rosenfeld Christopher W. Benner Hung-Ping Shih Maike Sander |
| author_facet |
Nicholas K. Vinckier Nisha A. Patel Ryan J. Geusz Allen Wang Jinzhao Wang Ileana Matta Austin R. Harrington Matthew Wortham Nichole Wetton Jianxun Wang Ulupi S. Jhala Michael G. Rosenfeld Christopher W. Benner Hung-Ping Shih Maike Sander |
| author_sort |
Nicholas K. Vinckier |
| title |
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| title_short |
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| title_full |
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| title_fullStr |
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| title_full_unstemmed |
LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| title_sort |
lsd1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/219e2bb5225f43dcb77d228c096f4de8 |
| work_keys_str_mv |
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| _version_ |
1718379988507426816 |