Accurate quantification of circular RNAs identifies extensive circular isoform switching events

Quantification and characterization of circRNAs in sequencing data remains challenging, hindering efforts to understand their roles and regulation. The algorithm introduced here enables accurate circRNA quantification and permits insight into competitive splicing between linear and circular isoforms...

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Autores principales:	Jinyang Zhang, Shuai Chen, Jingwen Yang, Fangqing Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/219f0d0bf5fa43b09bef99e959b408e2
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id	oai:doaj.org-article:219f0d0bf5fa43b09bef99e959b408e2
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spelling	oai:doaj.org-article:219f0d0bf5fa43b09bef99e959b408e22021-12-02T15:37:17ZAccurate quantification of circular RNAs identifies extensive circular isoform switching events10.1038/s41467-019-13840-92041-1723https://doaj.org/article/219f0d0bf5fa43b09bef99e959b408e22020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13840-9https://doaj.org/toc/2041-1723Quantification and characterization of circRNAs in sequencing data remains challenging, hindering efforts to understand their roles and regulation. The algorithm introduced here enables accurate circRNA quantification and permits insight into competitive splicing between linear and circular isoforms.Jinyang ZhangShuai ChenJingwen YangFangqing ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinyang Zhang Shuai Chen Jingwen Yang Fangqing Zhao Accurate quantification of circular RNAs identifies extensive circular isoform switching events
description	Quantification and characterization of circRNAs in sequencing data remains challenging, hindering efforts to understand their roles and regulation. The algorithm introduced here enables accurate circRNA quantification and permits insight into competitive splicing between linear and circular isoforms.
format	article
author	Jinyang Zhang Shuai Chen Jingwen Yang Fangqing Zhao
author_facet	Jinyang Zhang Shuai Chen Jingwen Yang Fangqing Zhao
author_sort	Jinyang Zhang
title	Accurate quantification of circular RNAs identifies extensive circular isoform switching events
title_short	Accurate quantification of circular RNAs identifies extensive circular isoform switching events
title_full	Accurate quantification of circular RNAs identifies extensive circular isoform switching events
title_fullStr	Accurate quantification of circular RNAs identifies extensive circular isoform switching events
title_full_unstemmed	Accurate quantification of circular RNAs identifies extensive circular isoform switching events
title_sort	accurate quantification of circular rnas identifies extensive circular isoform switching events
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/219f0d0bf5fa43b09bef99e959b408e2
work_keys_str_mv	AT jinyangzhang accuratequantificationofcircularrnasidentifiesextensivecircularisoformswitchingevents AT shuaichen accuratequantificationofcircularrnasidentifiesextensivecircularisoformswitchingevents AT jingwenyang accuratequantificationofcircularrnasidentifiesextensivecircularisoformswitchingevents AT fangqingzhao accuratequantificationofcircularrnasidentifiesextensivecircularisoformswitchingevents
_version_	1718386219747901440

Accurate quantification of circular RNAs identifies extensive circular isoform switching events

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