MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal

Summary: Tfcp2l1 can maintain mouse embryonic stem cell (mESC) self-renewal. However, it remains unknown how Tfcp2l1 protein stability is regulated. Here, we demonstrate that β-transducin repeat-containing protein (β-TrCP) targets Tfcp2l1 for ubiquitination and degradation in a mitogen-activated pro...

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Autores principales: Yan Zhang, Huiwen Ding, Xiaoxiao Wang, Xin Wang, Shengpeng Wan, Anchun Xu, Ruoyi Gan, Shou-Dong Ye
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
MK2
Acceso en línea:https://doaj.org/article/219f32317c2745a6baa0c76ec945fb8f
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