Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study

Abstract This study aimed to explore the associations between renal-related and arterial stiffness biomarkers with all-cause and expanded cardiovascular disease (CVD) mortality in a general Taiwanese population. This prospective community-based cohort study included 4883 subjects aged ≥ 20 years who...

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Autores principales:	Cheng-Chieh Lin, Ting-Yu Chen, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Mu-Cyun Wang, Shing-Yu Yang, Tsai-Chung Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21a26bf5c5894a34914116d0401d34d9
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spelling	oai:doaj.org-article:21a26bf5c5894a34914116d0401d34d92021-12-02T15:23:08ZRenal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study10.1038/s41598-021-93627-52045-2322https://doaj.org/article/21a26bf5c5894a34914116d0401d34d92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93627-5https://doaj.org/toc/2045-2322Abstract This study aimed to explore the associations between renal-related and arterial stiffness biomarkers with all-cause and expanded cardiovascular disease (CVD) mortality in a general Taiwanese population. This prospective community-based cohort study included 4883 subjects aged ≥ 20 years who were followed up until December 31, 2016. Renal-related biomarkers consisted of blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR). Arterial stiffness biomarker consisted of brachial-ankle pulse wave velocity (baPWV). The death status of the subjects was ascertained by matching information from death records with the identification number and date of birth of the subjects. Cox proportional hazard models with restricted cubic splines estimated the hazard ratios and 95% confidence intervals for all-cause mortality and expanded CVD mortality. During a mean 8.3 years of follow up, 456 deaths were recorded, 146 of which were due to expanded CVD mortality. The multivariable-adjusted hazard ratios of all-cause mortality was 1.53 (95% CI 1.21–1.94) for BUN (≥ 20 mg/dL vs. < 20 mg/dL), 1.57 (1.15–2.14) for eGFR (< 90 mL/min/1.73 m2 vs. ≥ 90 mL/min/1.73 m2), 1.55 (1.25–1.92) for UACR (≥ 30 mg/g vs. < 30 mg/g), and 1.75 (1.14–2.67) for baPWV (≥ 1400 cm/s vs. < 1400 cm/s). The expanded CVD mortality was 1.89 (95% CI 1.30–2.73) for BUN (≥ 20 mg/dL vs. < 20 mg/dL), 2.28 (1.13–4.57) for eGFR (< 90 mL/min/1.73 m2 vs. ≥ 90 mL/min/1.73 m2), 2.13 (1.52–2.99) for UACR (≥ 25 mg/g vs. < 25 mg/g), and 15.73 (2.14–115.61) for baPWV (≥ 1400 cm/s vs. < 1400 cm/s). High levels of BUN, UACR, and baPWV and low levels of eGFR showed high risks with all-cause and expanded CVD mortality. Our study provides insights into screening tests to target populations at high risk of premature death due to CVD.Cheng-Chieh LinTing-Yu ChenChia-Ing LiChiu-Shong LiuChih-Hsueh LinMu-Cyun WangShing-Yu YangTsai-Chung LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng-Chieh Lin Ting-Yu Chen Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Mu-Cyun Wang Shing-Yu Yang Tsai-Chung Li Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
description	Abstract This study aimed to explore the associations between renal-related and arterial stiffness biomarkers with all-cause and expanded cardiovascular disease (CVD) mortality in a general Taiwanese population. This prospective community-based cohort study included 4883 subjects aged ≥ 20 years who were followed up until December 31, 2016. Renal-related biomarkers consisted of blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), and urine albumin-to-creatinine ratio (UACR). Arterial stiffness biomarker consisted of brachial-ankle pulse wave velocity (baPWV). The death status of the subjects was ascertained by matching information from death records with the identification number and date of birth of the subjects. Cox proportional hazard models with restricted cubic splines estimated the hazard ratios and 95% confidence intervals for all-cause mortality and expanded CVD mortality. During a mean 8.3 years of follow up, 456 deaths were recorded, 146 of which were due to expanded CVD mortality. The multivariable-adjusted hazard ratios of all-cause mortality was 1.53 (95% CI 1.21–1.94) for BUN (≥ 20 mg/dL vs. < 20 mg/dL), 1.57 (1.15–2.14) for eGFR (< 90 mL/min/1.73 m2 vs. ≥ 90 mL/min/1.73 m2), 1.55 (1.25–1.92) for UACR (≥ 30 mg/g vs. < 30 mg/g), and 1.75 (1.14–2.67) for baPWV (≥ 1400 cm/s vs. < 1400 cm/s). The expanded CVD mortality was 1.89 (95% CI 1.30–2.73) for BUN (≥ 20 mg/dL vs. < 20 mg/dL), 2.28 (1.13–4.57) for eGFR (< 90 mL/min/1.73 m2 vs. ≥ 90 mL/min/1.73 m2), 2.13 (1.52–2.99) for UACR (≥ 25 mg/g vs. < 25 mg/g), and 15.73 (2.14–115.61) for baPWV (≥ 1400 cm/s vs. < 1400 cm/s). High levels of BUN, UACR, and baPWV and low levels of eGFR showed high risks with all-cause and expanded CVD mortality. Our study provides insights into screening tests to target populations at high risk of premature death due to CVD.
format	article
author	Cheng-Chieh Lin Ting-Yu Chen Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Mu-Cyun Wang Shing-Yu Yang Tsai-Chung Li
author_facet	Cheng-Chieh Lin Ting-Yu Chen Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Mu-Cyun Wang Shing-Yu Yang Tsai-Chung Li
author_sort	Cheng-Chieh Lin
title	Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
title_short	Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
title_full	Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
title_fullStr	Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
title_full_unstemmed	Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study
title_sort	renal markers and risks of all cause and cardiovascular mortality from the taichung community based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21a26bf5c5894a34914116d0401d34d9
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Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study

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