Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds

Here we report the use of forskolin-modified halloysite nanotubes (HNTs) as a dopant for biopolymer porous hydrogel scaffolds to impart osteoinductive properties. Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. This small molecule is widely used as a supplement in molecular...

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Autores principales:	Ekaterina Naumenko, Ivan Guryanov, Elena Zakirova, Rawil Fakhrullin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	forskolin biopolymers tissue engineering scaffolds halloysite nanotubes mesenchymal stem cells Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/21b49af209ee4d3fbd7068edbf186bed
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spelling	oai:doaj.org-article:21b49af209ee4d3fbd7068edbf186bed2021-11-25T18:48:41ZForskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds10.3390/polym132239492073-4360https://doaj.org/article/21b49af209ee4d3fbd7068edbf186bed2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3949https://doaj.org/toc/2073-4360Here we report the use of forskolin-modified halloysite nanotubes (HNTs) as a dopant for biopolymer porous hydrogel scaffolds to impart osteoinductive properties. Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. This small molecule is widely used as a supplement in molecular biology for cell differentiation. It has been reported in some earlier publications that forskolin can activate osteodifferentiation process by cyclic adenosine monophosphate (c-AMP) signalling activation in stem cells. In presented study it was demonstrated that forskolin release from halloysite-doped scaffolds induced the osteodifferentiation of equine mesenchymal stem cells (MSCs) in vitro without addition of any specific growth factors. The reinforcement of mechanical properties of cells and intercellular space during the osteodifferentiation was demonstrated using atomic force microscopy (AFM). These clay-doped scaffolds may find applications to accelerate the regeneration of horse bone defects by inducing the processes of osteodifferentiation of endogenous MSCs.Ekaterina NaumenkoIvan GuryanovElena ZakirovaRawil FakhrullinMDPI AGarticleforskolinbiopolymerstissue engineering scaffoldshalloysite nanotubesmesenchymal stem cellsOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3949, p 3949 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	forskolin biopolymers tissue engineering scaffolds halloysite nanotubes mesenchymal stem cells Organic chemistry QD241-441
spellingShingle	forskolin biopolymers tissue engineering scaffolds halloysite nanotubes mesenchymal stem cells Organic chemistry QD241-441 Ekaterina Naumenko Ivan Guryanov Elena Zakirova Rawil Fakhrullin Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
description	Here we report the use of forskolin-modified halloysite nanotubes (HNTs) as a dopant for biopolymer porous hydrogel scaffolds to impart osteoinductive properties. Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. This small molecule is widely used as a supplement in molecular biology for cell differentiation. It has been reported in some earlier publications that forskolin can activate osteodifferentiation process by cyclic adenosine monophosphate (c-AMP) signalling activation in stem cells. In presented study it was demonstrated that forskolin release from halloysite-doped scaffolds induced the osteodifferentiation of equine mesenchymal stem cells (MSCs) in vitro without addition of any specific growth factors. The reinforcement of mechanical properties of cells and intercellular space during the osteodifferentiation was demonstrated using atomic force microscopy (AFM). These clay-doped scaffolds may find applications to accelerate the regeneration of horse bone defects by inducing the processes of osteodifferentiation of endogenous MSCs.
format	article
author	Ekaterina Naumenko Ivan Guryanov Elena Zakirova Rawil Fakhrullin
author_facet	Ekaterina Naumenko Ivan Guryanov Elena Zakirova Rawil Fakhrullin
author_sort	Ekaterina Naumenko
title	Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
title_short	Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
title_full	Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
title_fullStr	Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
title_full_unstemmed	Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds
title_sort	forskolin-loaded halloysite nanotubes as osteoconductive additive for the biopolymer tissue engineering scaffolds
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/21b49af209ee4d3fbd7068edbf186bed
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Forskolin-Loaded Halloysite Nanotubes as Osteoconductive Additive for the Biopolymer Tissue Engineering Scaffolds

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