Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses

Beatrice Bortolato,1 Kamilla W Miskowiak,2 Cristiano A Köhler,3 Eduard Vieta,4 André F Carvalho3 1Department of Mental Health, ULSS 10 “Veneto Orientale”, Venice, Italy; 2Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhage...

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Autores principales:	Bortolato B, Miskowiak KW, Köhler CA, Vieta E, Carvalho AF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	schizophrenia bipolar disorder psychosis neuropsychological tests cognition meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/21b6f80f5c8641a0a4baf384f1ae701e
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spelling	oai:doaj.org-article:21b6f80f5c8641a0a4baf384f1ae701e2021-12-02T02:31:50ZCognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses1178-2021https://doaj.org/article/21b6f80f5c8641a0a4baf384f1ae701e2015-12-01T00:00:00Zhttps://www.dovepress.com/cognitive-dysfunction-in-bipolar-disorder-and-schizophrenia-a-systemat-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Beatrice Bortolato,1 Kamilla W Miskowiak,2 Cristiano A Köhler,3 Eduard Vieta,4 André F Carvalho3 1Department of Mental Health, ULSS 10 “Veneto Orientale”, Venice, Italy; 2Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil; 4Bipolar Disorders Program, Institute of Neuroscience, Hospital Clínic Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Catalonia, Spain Abstract: Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A neurocognitive profile characterized by widespread cognitive deficits across multiple domains in the context of substantial intellectual impairment, which appears to antedate illness onset, is a replicated finding in SZ. There is no specific neuropsychological signature that can facilitate the diagnostic differentiation of SZ and BD, notwithstanding, neuropsychological deficits appear more severe in SZ. The literature in this field has provided contradictory results due to methodological differences across studies. Meta-analytic techniques may offer an opportunity to synthesize findings and to control for potential sources of heterogeneity. Here, we performed a systematic review of meta-analyses of neuropsychological findings in SZ and BD. While there is no conclusive evidence for progressive cognitive deterioration in either SZ or BD, some findings point to more severe cognitive deficits in patients with early illness onset across both disorders. A compromised pattern of cognitive functioning in individuals at familiar and/or clinical risk to psychosis as well as in first-degree relatives of BD patients suggests that early neurodevelopmental factors may play a role in the emergence of cognitive deficits in both disorders. Premorbid intellectual impairment in SZ and at least in a subgroup of patients with BD may be related to a shared genetically determined influence on neurodevelopment. Keywords: schizophrenia, bipolar disorder, psychosis, neuropsychological tests, cognition, meta-analysis, psychiatryBortolato BMiskowiak KWKöhler CAVieta ECarvalho AFDove Medical Pressarticleschizophreniabipolar disorderpsychosisneuropsychological testscognitionmeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss Issue 1, Pp 3111-3125 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia bipolar disorder psychosis neuropsychological tests cognition meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia bipolar disorder psychosis neuropsychological tests cognition meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bortolato B Miskowiak KW Köhler CA Vieta E Carvalho AF Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
description	Beatrice Bortolato,1 Kamilla W Miskowiak,2 Cristiano A Köhler,3 Eduard Vieta,4 André F Carvalho3 1Department of Mental Health, ULSS 10 “Veneto Orientale”, Venice, Italy; 2Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil; 4Bipolar Disorders Program, Institute of Neuroscience, Hospital Clínic Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Catalonia, Spain Abstract: Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A neurocognitive profile characterized by widespread cognitive deficits across multiple domains in the context of substantial intellectual impairment, which appears to antedate illness onset, is a replicated finding in SZ. There is no specific neuropsychological signature that can facilitate the diagnostic differentiation of SZ and BD, notwithstanding, neuropsychological deficits appear more severe in SZ. The literature in this field has provided contradictory results due to methodological differences across studies. Meta-analytic techniques may offer an opportunity to synthesize findings and to control for potential sources of heterogeneity. Here, we performed a systematic review of meta-analyses of neuropsychological findings in SZ and BD. While there is no conclusive evidence for progressive cognitive deterioration in either SZ or BD, some findings point to more severe cognitive deficits in patients with early illness onset across both disorders. A compromised pattern of cognitive functioning in individuals at familiar and/or clinical risk to psychosis as well as in first-degree relatives of BD patients suggests that early neurodevelopmental factors may play a role in the emergence of cognitive deficits in both disorders. Premorbid intellectual impairment in SZ and at least in a subgroup of patients with BD may be related to a shared genetically determined influence on neurodevelopment. Keywords: schizophrenia, bipolar disorder, psychosis, neuropsychological tests, cognition, meta-analysis, psychiatry
format	article
author	Bortolato B Miskowiak KW Köhler CA Vieta E Carvalho AF
author_facet	Bortolato B Miskowiak KW Köhler CA Vieta E Carvalho AF
author_sort	Bortolato B
title	Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
title_short	Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
title_full	Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
title_fullStr	Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
title_full_unstemmed	Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
title_sort	cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/21b6f80f5c8641a0a4baf384f1ae701e
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Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses

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