Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy

Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contributes to the CMT-like phenotype.

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Autores principales:	Sven Bervoets, Na Wei, Maria-Luise Erfurth, Shazie Yusein-Myashkova, Biljana Ermanoska, Ligia Mateiu, Bob Asselbergh, David Blocquel, Priyanka Kakad, Tyrone Penserga, Florian P Thomas, Velina Guergueltcheva, Ivailo Tournev, Tanja Godenschwege, Albena Jordanova, Xiang-Lei Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21bb42563b3e4403b71172f684a5c1f1
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spelling	oai:doaj.org-article:21bb42563b3e4403b71172f684a5c1f12021-12-02T14:39:38ZTranscriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy10.1038/s41467-019-12909-92041-1723https://doaj.org/article/21bb42563b3e4403b71172f684a5c1f12019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12909-9https://doaj.org/toc/2041-1723Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contributes to the CMT-like phenotype.Sven BervoetsNa WeiMaria-Luise ErfurthShazie Yusein-MyashkovaBiljana ErmanoskaLigia MateiuBob AsselberghDavid BlocquelPriyanka KakadTyrone PensergaFlorian P ThomasVelina GuergueltchevaIvailo TournevTanja GodenschwegeAlbena JordanovaXiang-Lei YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sven Bervoets Na Wei Maria-Luise Erfurth Shazie Yusein-Myashkova Biljana Ermanoska Ligia Mateiu Bob Asselbergh David Blocquel Priyanka Kakad Tyrone Penserga Florian P Thomas Velina Guergueltcheva Ivailo Tournev Tanja Godenschwege Albena Jordanova Xiang-Lei Yang Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
description	Tyrosyl-tRNA synthetase (TyrRS) is a translation factor and predominantly cytoplasmic, but can also be found in the nucleus. Here authors show using a fly model of Charcot-Marie-Tooth (CMT) disease that nuclear localization of mutant TyrRS contributes to the CMT-like phenotype.
format	article
author	Sven Bervoets Na Wei Maria-Luise Erfurth Shazie Yusein-Myashkova Biljana Ermanoska Ligia Mateiu Bob Asselbergh David Blocquel Priyanka Kakad Tyrone Penserga Florian P Thomas Velina Guergueltcheva Ivailo Tournev Tanja Godenschwege Albena Jordanova Xiang-Lei Yang
author_facet	Sven Bervoets Na Wei Maria-Luise Erfurth Shazie Yusein-Myashkova Biljana Ermanoska Ligia Mateiu Bob Asselbergh David Blocquel Priyanka Kakad Tyrone Penserga Florian P Thomas Velina Guergueltcheva Ivailo Tournev Tanja Godenschwege Albena Jordanova Xiang-Lei Yang
author_sort	Sven Bervoets
title	Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
title_short	Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
title_full	Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
title_fullStr	Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
title_full_unstemmed	Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy
title_sort	transcriptional dysregulation by a nucleus-localized aminoacyl-trna synthetase associated with charcot-marie-tooth neuropathy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/21bb42563b3e4403b71172f684a5c1f1
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Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy

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