pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Zhiwen Cao,1 Wen Li,1 Rui Liu,1 Chenxi Li,1 Yurong Song,1 Guangzhi Liu,1 Youwen Chen,1 Cheng Lu,2 Aiping Lu,3 Yuanyan Liu1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China; 2Institute of Basic Research in Clinical Medicin...

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Autores principales:	Cao Z, Li W, Liu R, Li C, Song Y, Liu G, Chen Y, Lu C, Lu A, Liu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	auraptene cisplatin cell imaging tumor targeting ph- responsive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/21bc02e371994cbaa3d70bed675c8174
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spelling	oai:doaj.org-article:21bc02e371994cbaa3d70bed675c81742021-12-02T11:38:40ZpH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer1178-2013https://doaj.org/article/21bc02e371994cbaa3d70bed675c81742020-10-01T00:00:00Zhttps://www.dovepress.com/ph-responsive-fluorescence-enhanced-nanogel-for-targeted-delivery-of-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhiwen Cao,1 Wen Li,1 Rui Liu,1 Chenxi Li,1 Yurong Song,1 Guangzhi Liu,1 Youwen Chen,1 Cheng Lu,2 Aiping Lu,3 Yuanyan Liu1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, People’s Republic of China; 3School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hongkong, People’s Republic of ChinaCorrespondence: Yuanyan Liu; Aiping Lu Tel +86 10 84738658Email yyliu_1980@163.com; lap64067611@126.comIntroduction: Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.Methods: Therefore, the biodegradable materials hyaluronic acid (HA) and β-cyclodextrin derivative (mono-(6-amino-mono-6-deoxy)-β-CD, CD) were employed as carriers to load AUR and CDDP to form nanogel (CDDPHA-CD@AUR) capable of dual-targeted delivery and synergistic therapy for breast cancer and cell imaging.Results: With the help of the CDDP-crosslinked CD-loaded structure, the newly synthesized nanogel exhibited excellent physiological stability and fluorescence effects. The release of AUR and CDDP was affected by the pH value, which was beneficial to the selective release in the tumor microenvironment. Cell experiments in vitro demonstrated that the nanogel could be selectively internalized by MCF-7 cells and exhibited low cytotoxicity to HK-2 cells. Antitumor experiments in vivo showed that the nanogel have better antitumor effects and lower systemic toxicity.Conclusion: Based on these, the nanogel loaded with AUR and CDDP have the potential for targeted delivery against breast cancer.Keywords: auraptene, cisplatin, cell imaging, tumor targeting, pH-responsiveCao ZLi WLiu RLi CSong YLiu GChen YLu CLu ALiu YDove Medical Pressarticleauraptenecisplatincell imagingtumor targetingph- responsiveMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8369-8382 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	auraptene cisplatin cell imaging tumor targeting ph- responsive Medicine (General) R5-920
spellingShingle	auraptene cisplatin cell imaging tumor targeting ph- responsive Medicine (General) R5-920 Cao Z Li W Liu R Li C Song Y Liu G Chen Y Lu C Lu A Liu Y pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
description	Zhiwen Cao,1 Wen Li,1 Rui Liu,1 Chenxi Li,1 Yurong Song,1 Guangzhi Liu,1 Youwen Chen,1 Cheng Lu,2 Aiping Lu,3 Yuanyan Liu1 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, People’s Republic of China; 3School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hongkong, People’s Republic of ChinaCorrespondence: Yuanyan Liu; Aiping Lu Tel +86 10 84738658Email yyliu_1980@163.com; lap64067611@126.comIntroduction: Auraptene (AUR), a natural bioactive prenyloxy coumarin, is a highly pleiotropic molecule that can bind to the MT1 receptor and can effectively reduce the proliferation and migration of breast cancer cells. Cisplatin (CDDP), as the first synthetic platinum-based anticancer drug, is widely used in the clinic due to its definite mechanism and therapeutic effect on diverse tumors. However, both of AUR and CDDP exhibit some disadvantages when used alone, including poor solubility, low bioavailability, lack of selectivity and systemic toxicity when they are used singly.Methods: Therefore, the biodegradable materials hyaluronic acid (HA) and β-cyclodextrin derivative (mono-(6-amino-mono-6-deoxy)-β-CD, CD) were employed as carriers to load AUR and CDDP to form nanogel (CDDPHA-CD@AUR) capable of dual-targeted delivery and synergistic therapy for breast cancer and cell imaging.Results: With the help of the CDDP-crosslinked CD-loaded structure, the newly synthesized nanogel exhibited excellent physiological stability and fluorescence effects. The release of AUR and CDDP was affected by the pH value, which was beneficial to the selective release in the tumor microenvironment. Cell experiments in vitro demonstrated that the nanogel could be selectively internalized by MCF-7 cells and exhibited low cytotoxicity to HK-2 cells. Antitumor experiments in vivo showed that the nanogel have better antitumor effects and lower systemic toxicity.Conclusion: Based on these, the nanogel loaded with AUR and CDDP have the potential for targeted delivery against breast cancer.Keywords: auraptene, cisplatin, cell imaging, tumor targeting, pH-responsive
format	article
author	Cao Z Li W Liu R Li C Song Y Liu G Chen Y Lu C Lu A Liu Y
author_facet	Cao Z Li W Liu R Li C Song Y Liu G Chen Y Lu C Lu A Liu Y
author_sort	Cao Z
title	pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
title_short	pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
title_full	pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
title_fullStr	pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
title_full_unstemmed	pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer
title_sort	ph-responsive fluorescence enhanced nanogel for targeted delivery of aur and cddp against breast cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/21bc02e371994cbaa3d70bed675c8174
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pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

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