Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines

The stereoselective addition of Grignard reagents to ketimines is potentially a straightforward route to α-chiral amines. Here the authors report a catalytic, asymmetric Grignard addition to silyl ketimines, givingN-sulfonyl protected α-chiral silyl amines with tetrasubstituted stereocentres.

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Autores principales:	Jiawei Rong, Juan F. Collados, Pablo Ortiz, Ravindra P. Jumde, Edwin Otten, Syuzanna R. Harutyunyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21be2c4928f94b7f9adb7908f0ebc4c3
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spelling	oai:doaj.org-article:21be2c4928f94b7f9adb7908f0ebc4c32021-12-02T15:35:19ZCatalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines10.1038/ncomms137802041-1723https://doaj.org/article/21be2c4928f94b7f9adb7908f0ebc4c32016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13780https://doaj.org/toc/2041-1723The stereoselective addition of Grignard reagents to ketimines is potentially a straightforward route to α-chiral amines. Here the authors report a catalytic, asymmetric Grignard addition to silyl ketimines, givingN-sulfonyl protected α-chiral silyl amines with tetrasubstituted stereocentres.Jiawei RongJuan F. ColladosPablo OrtizRavindra P. JumdeEdwin OttenSyuzanna R. HarutyunyanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiawei Rong Juan F. Collados Pablo Ortiz Ravindra P. Jumde Edwin Otten Syuzanna R. Harutyunyan Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
description	The stereoselective addition of Grignard reagents to ketimines is potentially a straightforward route to α-chiral amines. Here the authors report a catalytic, asymmetric Grignard addition to silyl ketimines, givingN-sulfonyl protected α-chiral silyl amines with tetrasubstituted stereocentres.
format	article
author	Jiawei Rong Juan F. Collados Pablo Ortiz Ravindra P. Jumde Edwin Otten Syuzanna R. Harutyunyan
author_facet	Jiawei Rong Juan F. Collados Pablo Ortiz Ravindra P. Jumde Edwin Otten Syuzanna R. Harutyunyan
author_sort	Jiawei Rong
title	Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
title_short	Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
title_full	Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
title_fullStr	Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
title_full_unstemmed	Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
title_sort	catalytic enantioselective addition of grignard reagents to aromatic silyl ketimines
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/21be2c4928f94b7f9adb7908f0ebc4c3
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Catalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines

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