Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.

<h4>Background</h4>Mercury is a neurotoxicant linked with psychiatric symptoms at high levels of exposure. However, it is unclear whether an association is present at the low exposure levels in the US adult population.<h4>Materials and methods</h4>Cross-sectional associations...

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Autores principales:	Tsz Hin H Ng, Jana M Mossey, Brian K Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21bfd587d29c441084df19a66c10d2ab
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spelling	oai:doaj.org-article:21bfd587d29c441084df19a66c10d2ab2021-11-18T08:47:25ZTotal blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.1932-620310.1371/journal.pone.0079339https://doaj.org/article/21bfd587d29c441084df19a66c10d2ab2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244482/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Mercury is a neurotoxicant linked with psychiatric symptoms at high levels of exposure. However, it is unclear whether an association is present at the low exposure levels in the US adult population.<h4>Materials and methods</h4>Cross-sectional associations of total blood mercury and depression were assessed in 6,911 adults age ≥20 in the National Health and Nutrition Examination Survey (NHANES), 2005-2008. The Patient Health Questionnaire-9 was used to assess depression (high likelihood of a depressive spectrum disorder diagnosis; score 5-27).<h4>Results</h4>Unadjusted survey weighted logistic regression suggested that higher total blood mercury was associated with lower odds of depression (Odds Ratio = 0.49, 95% Confidence Interval: 0.36-0.65, comparing the highest and lowest mercury quintiles). This association largely disappeared after adjustment for sociodemographic variables (income-poverty ratio, education, marital status). However, in age-stratified analyses, this inverse relationship remained in older adults (age ≥40) even after adjustment for sociodemographic variables. Simulation analyses adjusting for expected confounding effects of fish intake suggested that the inverse relationship among older adults may be plausibly attributed to residual confounding (Odds Ratio = 0.75, 95% Confidence Interval: 0.50-1.12, comparing the highest and lowest mercury quintiles).<h4>Conclusions</h4>Higher total blood mercury was not associated with increased odds of depression. The lower odds of depression in older adults with higher total blood mercury may be due to residual confounding.Tsz Hin H NgJana M MosseyBrian K LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79339 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsz Hin H Ng Jana M Mossey Brian K Lee Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
description	<h4>Background</h4>Mercury is a neurotoxicant linked with psychiatric symptoms at high levels of exposure. However, it is unclear whether an association is present at the low exposure levels in the US adult population.<h4>Materials and methods</h4>Cross-sectional associations of total blood mercury and depression were assessed in 6,911 adults age ≥20 in the National Health and Nutrition Examination Survey (NHANES), 2005-2008. The Patient Health Questionnaire-9 was used to assess depression (high likelihood of a depressive spectrum disorder diagnosis; score 5-27).<h4>Results</h4>Unadjusted survey weighted logistic regression suggested that higher total blood mercury was associated with lower odds of depression (Odds Ratio = 0.49, 95% Confidence Interval: 0.36-0.65, comparing the highest and lowest mercury quintiles). This association largely disappeared after adjustment for sociodemographic variables (income-poverty ratio, education, marital status). However, in age-stratified analyses, this inverse relationship remained in older adults (age ≥40) even after adjustment for sociodemographic variables. Simulation analyses adjusting for expected confounding effects of fish intake suggested that the inverse relationship among older adults may be plausibly attributed to residual confounding (Odds Ratio = 0.75, 95% Confidence Interval: 0.50-1.12, comparing the highest and lowest mercury quintiles).<h4>Conclusions</h4>Higher total blood mercury was not associated with increased odds of depression. The lower odds of depression in older adults with higher total blood mercury may be due to residual confounding.
format	article
author	Tsz Hin H Ng Jana M Mossey Brian K Lee
author_facet	Tsz Hin H Ng Jana M Mossey Brian K Lee
author_sort	Tsz Hin H Ng
title	Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
title_short	Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
title_full	Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
title_fullStr	Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
title_full_unstemmed	Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.
title_sort	total blood mercury levels and depression among adults in the united states: national health and nutrition examination survey 2005-2008.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/21bfd587d29c441084df19a66c10d2ab
work_keys_str_mv	AT tszhinhng totalbloodmercurylevelsanddepressionamongadultsintheunitedstatesnationalhealthandnutritionexaminationsurvey20052008 AT janammossey totalbloodmercurylevelsanddepressionamongadultsintheunitedstatesnationalhealthandnutritionexaminationsurvey20052008 AT brianklee totalbloodmercurylevelsanddepressionamongadultsintheunitedstatesnationalhealthandnutritionexaminationsurvey20052008
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Total blood mercury levels and depression among adults in the United States: National Health and Nutrition Examination Survey 2005-2008.

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