Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease

In the last decades, the global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached pandemic proportions with derived major health and socioeconomic consequences; this tendency is expected to be further aggravated in the coming years. Obesity, insulin resistance/type 2 diabetes melli...

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Autores principales:	José Ignacio Martínez-Montoro, Isabel Cornejo-Pareja, Ana María Gómez-Pérez, Francisco J. Tinahones
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-alcoholic fatty liver disease gene polymorphism dietary intervention gene-nutrient interactions bariatric surgery pharmacotherapy Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/21c12234cddf4052bd76037c1ed66109
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spelling	oai:doaj.org-article:21c12234cddf4052bd76037c1ed661092021-11-25T18:36:35ZImpact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease10.3390/nu131140772072-6643https://doaj.org/article/21c12234cddf4052bd76037c1ed661092021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4077https://doaj.org/toc/2072-6643In the last decades, the global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached pandemic proportions with derived major health and socioeconomic consequences; this tendency is expected to be further aggravated in the coming years. Obesity, insulin resistance/type 2 diabetes mellitus, sedentary lifestyle, increased caloric intake and genetic predisposition constitute the main risk factors associated with the development and progression of the disease. Importantly, the interaction between the inherited genetic background and some unhealthy dietary patterns has been postulated to have an essential role in the pathogenesis of NAFLD. Weight loss through lifestyle modifications is considered the cornerstone of the treatment for NAFLD and the inter-individual variability in the response to some dietary approaches may be conditioned by the presence of different single nucleotide polymorphisms. In this review, we summarize the current evidence on the influence of the association between genetic susceptibility and dietary habits in NAFLD pathophysiology, as well as the role of gene polymorphism in the response to lifestyle interventions and the potential interaction between nutritional genomics and other emerging therapies for NAFLD, such as bariatric surgery and several pharmacologic agents.José Ignacio Martínez-MontoroIsabel Cornejo-ParejaAna María Gómez-PérezFrancisco J. TinahonesMDPI AGarticlenon-alcoholic fatty liver diseasegene polymorphismdietary interventiongene-nutrient interactionsbariatric surgerypharmacotherapyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4077, p 4077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease gene polymorphism dietary intervention gene-nutrient interactions bariatric surgery pharmacotherapy Nutrition. Foods and food supply TX341-641
spellingShingle	non-alcoholic fatty liver disease gene polymorphism dietary intervention gene-nutrient interactions bariatric surgery pharmacotherapy Nutrition. Foods and food supply TX341-641 José Ignacio Martínez-Montoro Isabel Cornejo-Pareja Ana María Gómez-Pérez Francisco J. Tinahones Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
description	In the last decades, the global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached pandemic proportions with derived major health and socioeconomic consequences; this tendency is expected to be further aggravated in the coming years. Obesity, insulin resistance/type 2 diabetes mellitus, sedentary lifestyle, increased caloric intake and genetic predisposition constitute the main risk factors associated with the development and progression of the disease. Importantly, the interaction between the inherited genetic background and some unhealthy dietary patterns has been postulated to have an essential role in the pathogenesis of NAFLD. Weight loss through lifestyle modifications is considered the cornerstone of the treatment for NAFLD and the inter-individual variability in the response to some dietary approaches may be conditioned by the presence of different single nucleotide polymorphisms. In this review, we summarize the current evidence on the influence of the association between genetic susceptibility and dietary habits in NAFLD pathophysiology, as well as the role of gene polymorphism in the response to lifestyle interventions and the potential interaction between nutritional genomics and other emerging therapies for NAFLD, such as bariatric surgery and several pharmacologic agents.
format	article
author	José Ignacio Martínez-Montoro Isabel Cornejo-Pareja Ana María Gómez-Pérez Francisco J. Tinahones
author_facet	José Ignacio Martínez-Montoro Isabel Cornejo-Pareja Ana María Gómez-Pérez Francisco J. Tinahones
author_sort	José Ignacio Martínez-Montoro
title	Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
title_short	Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
title_full	Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
title_fullStr	Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
title_full_unstemmed	Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease
title_sort	impact of genetic polymorphism on response to therapy in non-alcoholic fatty liver disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/21c12234cddf4052bd76037c1ed66109
work_keys_str_mv	AT joseignaciomartinezmontoro impactofgeneticpolymorphismonresponsetotherapyinnonalcoholicfattyliverdisease AT isabelcornejopareja impactofgeneticpolymorphismonresponsetotherapyinnonalcoholicfattyliverdisease AT anamariagomezperez impactofgeneticpolymorphismonresponsetotherapyinnonalcoholicfattyliverdisease AT franciscojtinahones impactofgeneticpolymorphismonresponsetotherapyinnonalcoholicfattyliverdisease
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Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic Fatty Liver Disease

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