Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice

Background and Aims: Anxiety is one of the symptoms of menopause, which is due to stopping of ovarian activity. The aim of this study was to investigate the effect of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice.Methods: Eighty female mice weighing 25-30 g and aged...

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Autores principales:	Saeid Arzhang, Mahmoud Rafieian Kopaei, Hossein Amini-Khoei, Elham Bijad, Zahra Alibabaie, Soleiman Kheiri, Nahid Jivad
Formato:	article
Lenguaje:	EN
Publicado:	Shahrekord University of Medical Sciences 2021
Materias:	foeniculum vulgare l anxiety antioxidant capacity malondialdehyde Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21c27f1d149d47afafaf7bc178177f8c
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spelling	oai:doaj.org-article:21c27f1d149d47afafaf7bc178177f8c2021-11-13T05:12:32ZEffects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice2423-3579https://doaj.org/article/21c27f1d149d47afafaf7bc178177f8c2021-07-01T00:00:00Zhttp://herbmed.skums.ac.ir/article_245143_ab7690ff7ce5f8a752bbabbbb0c3fc3c.pdfhttps://doaj.org/toc/2423-3579Background and Aims: Anxiety is one of the symptoms of menopause, which is due to stopping of ovarian activity. The aim of this study was to investigate the effect of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice.Methods: Eighty female mice weighing 25-30 g and aged 6-8 weeks were divided into 10 groups of eight each, controls: the group without ovariectomy given distilled water, positive controls: the ovariectomized group receiving 40 µg/kg of estradiol valerate, the groups without ovariectomy given F. vulgare extract by gavage at 200, 500, and 750 mg/kg, the ovariectomized group given distilled water, the ovariectomized groups given F. vulgare extract at 200, 500, and 750 mg/kg, and the ovariectomized group given diazepam at 1 mg/kg. Elevated plus maze (EPM) and open field were used to investigate anxiety in mice. The level of malondialdehyde (MDA) and total antioxidant capacity (TAC) of the brain and serum were also measured. Results: In ovariectomized mice, the number of entries to the closed arms of EPM was significantly increased compared with control group (P<0.05). Treatment of ovariectomized mice with 500 and 750 mg/kg of the extract significantly increased the number of entries to the open arms and significantly decreased the number of entries to the closed arms of EPM (P<0.05). The time spent in the center and the crossing squares in the open field significantly decreased in ovariectomized mice compared with control group and treatment with estradiol significantly increased them (P<0.05). In ovariectomized mice, serum and brain MDA levels significantly increased and their TAC significantly decreased compared with control group. Different doses of extract, estradiol and diazepam significantly reduced MDA levels and increased TAC in both brain and serum (P<0.05).Conclusion: vulgare extract may ameliorate the symptoms of anxiety in ovariectomized mice by reducing oxidative stress.Saeid ArzhangMahmoud Rafieian KopaeiHossein Amini-KhoeiElham BijadZahra AlibabaieSoleiman KheiriNahid JivadShahrekord University of Medical Sciencesarticlefoeniculum vulgare lanxietyantioxidant capacitymalondialdehydeMedicineRScienceQENAdvanced Herbal Medicine , Vol 6, Iss 2, Pp 17-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	foeniculum vulgare l anxiety antioxidant capacity malondialdehyde Medicine R Science Q
spellingShingle	foeniculum vulgare l anxiety antioxidant capacity malondialdehyde Medicine R Science Q Saeid Arzhang Mahmoud Rafieian Kopaei Hossein Amini-Khoei Elham Bijad Zahra Alibabaie Soleiman Kheiri Nahid Jivad Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
description	Background and Aims: Anxiety is one of the symptoms of menopause, which is due to stopping of ovarian activity. The aim of this study was to investigate the effect of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice.Methods: Eighty female mice weighing 25-30 g and aged 6-8 weeks were divided into 10 groups of eight each, controls: the group without ovariectomy given distilled water, positive controls: the ovariectomized group receiving 40 µg/kg of estradiol valerate, the groups without ovariectomy given F. vulgare extract by gavage at 200, 500, and 750 mg/kg, the ovariectomized group given distilled water, the ovariectomized groups given F. vulgare extract at 200, 500, and 750 mg/kg, and the ovariectomized group given diazepam at 1 mg/kg. Elevated plus maze (EPM) and open field were used to investigate anxiety in mice. The level of malondialdehyde (MDA) and total antioxidant capacity (TAC) of the brain and serum were also measured. Results: In ovariectomized mice, the number of entries to the closed arms of EPM was significantly increased compared with control group (P<0.05). Treatment of ovariectomized mice with 500 and 750 mg/kg of the extract significantly increased the number of entries to the open arms and significantly decreased the number of entries to the closed arms of EPM (P<0.05). The time spent in the center and the crossing squares in the open field significantly decreased in ovariectomized mice compared with control group and treatment with estradiol significantly increased them (P<0.05). In ovariectomized mice, serum and brain MDA levels significantly increased and their TAC significantly decreased compared with control group. Different doses of extract, estradiol and diazepam significantly reduced MDA levels and increased TAC in both brain and serum (P<0.05).Conclusion: vulgare extract may ameliorate the symptoms of anxiety in ovariectomized mice by reducing oxidative stress.
format	article
author	Saeid Arzhang Mahmoud Rafieian Kopaei Hossein Amini-Khoei Elham Bijad Zahra Alibabaie Soleiman Kheiri Nahid Jivad
author_facet	Saeid Arzhang Mahmoud Rafieian Kopaei Hossein Amini-Khoei Elham Bijad Zahra Alibabaie Soleiman Kheiri Nahid Jivad
author_sort	Saeid Arzhang
title	Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
title_short	Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
title_full	Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
title_fullStr	Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
title_full_unstemmed	Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice
title_sort	effects of foeniculum vulgare l. extract on anxiety-like behaviors in ovariectomized mice
publisher	Shahrekord University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/21c27f1d149d47afafaf7bc178177f8c
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Effects of Foeniculum vulgare L. extract on anxiety-like behaviors in ovariectomized mice

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