Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia

Getachew Bisetegn,1 Mastewal Arefaynie,2 Anissa Mohammed,3 Zinabu Fentaw,3 Amare Muche,3 Reta Dewau,3 Yimer Seid1 1Dessie City Zonal Health Department, CDC-Ethiopia, Dessie, Ethiopia; 2Department of Reproductive and Family Health, School of Public Health, College of Medicine and Health Science, Woll...

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Autores principales:	Bisetegn G, Arefaynie M, Mohammed A, Fentaw Z, Muche A, Dewau R, Seid Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hiv/aids enhanced adherence counseling virological failure case-control ethiopia. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/21c290a0621f460dbd89608d82cdf009
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spelling	oai:doaj.org-article:21c290a0621f460dbd89608d82cdf0092021-12-02T14:08:52ZPredictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia1179-1373https://doaj.org/article/21c290a0621f460dbd89608d82cdf0092021-01-01T00:00:00Zhttps://www.dovepress.com/predictors-of-virological-failure-after-adherence-enhancement-counseli-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Getachew Bisetegn,1 Mastewal Arefaynie,2 Anissa Mohammed,3 Zinabu Fentaw,3 Amare Muche,3 Reta Dewau,3 Yimer Seid1 1Dessie City Zonal Health Department, CDC-Ethiopia, Dessie, Ethiopia; 2Department of Reproductive and Family Health, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia; 3Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaCorrespondence: Zinabu FentawDepartment of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaTel +251-91-275-7286Email zfentaw5@gmail.comBackground: HIV virological failure is a common challenging problem, even after adherence-enhancement counseling. However, there have been few studies on the determinants of virological failure after adherence-enhancement counseling among adult patients on antiretroviral therapy in Ethiopia in general, and there is variation across clients and settings for unknown reasons. Therefore, this study aimed to identify predictors of virological failure after adherence-enhancement counseling among adults living with HIV/AIDS.Methods: A case–control study was conducted in the town of Kombolcha from January 1, 2019 to March 30, 2019 using simple random sampling for 338 participants. Data were collected through face-to-face interviews for social and personal characteristics and document review for clinical profiles. Descriptive statistics were used for frequency, proportions, and summary measures. Binary logistic regression analysis was carried out to identify the predictors of virological failure after adherence-enhancement counseling among adults. For multivariate logistic regression,P< 0.05 was considered statistically significant. AORs are presented with 95% CIs.Results: The odds of virological failure after adherence-enhancement counseling were higher following poor antiretroviral medication adherence (AOR 7.3, 95% CI 2.57– 20.79) and for patients who had had a first high viral load (≥ 10,000 copies/mL, (AOR 5, 95% CI 1.86– 13.56) and a history of opportunistic infection (AOR 3.7, 95% CI 1.11– 8.44) compared with their counterparts.Conclusion: Poor antiretroviral medication adherence during adherence-enhancement counseling session, first viral load ≥ 10,000 copies/mL, and recent history of opportunistic infection were predictors of virological failure. Therefore, efforts should be strengthened to improve adherence to antiretroviral medication, which helps to boost immunity and suppress viral replication.Keywords: HIV/AIDS, adherence-enhancement counseling, virological failure, case–control, EthiopiaBisetegn GArefaynie MMohammed AFentaw ZMuche ADewau RSeid YDove Medical Pressarticlehiv/aidsenhanced adherence counselingvirological failurecase-controlethiopia.Immunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 91-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv/aids enhanced adherence counseling virological failure case-control ethiopia. Immunologic diseases. Allergy RC581-607
spellingShingle	hiv/aids enhanced adherence counseling virological failure case-control ethiopia. Immunologic diseases. Allergy RC581-607 Bisetegn G Arefaynie M Mohammed A Fentaw Z Muche A Dewau R Seid Y Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
description	Getachew Bisetegn,1 Mastewal Arefaynie,2 Anissa Mohammed,3 Zinabu Fentaw,3 Amare Muche,3 Reta Dewau,3 Yimer Seid1 1Dessie City Zonal Health Department, CDC-Ethiopia, Dessie, Ethiopia; 2Department of Reproductive and Family Health, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia; 3Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaCorrespondence: Zinabu FentawDepartment of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Wollo University, Dessie, EthiopiaTel +251-91-275-7286Email zfentaw5@gmail.comBackground: HIV virological failure is a common challenging problem, even after adherence-enhancement counseling. However, there have been few studies on the determinants of virological failure after adherence-enhancement counseling among adult patients on antiretroviral therapy in Ethiopia in general, and there is variation across clients and settings for unknown reasons. Therefore, this study aimed to identify predictors of virological failure after adherence-enhancement counseling among adults living with HIV/AIDS.Methods: A case–control study was conducted in the town of Kombolcha from January 1, 2019 to March 30, 2019 using simple random sampling for 338 participants. Data were collected through face-to-face interviews for social and personal characteristics and document review for clinical profiles. Descriptive statistics were used for frequency, proportions, and summary measures. Binary logistic regression analysis was carried out to identify the predictors of virological failure after adherence-enhancement counseling among adults. For multivariate logistic regression,P< 0.05 was considered statistically significant. AORs are presented with 95% CIs.Results: The odds of virological failure after adherence-enhancement counseling were higher following poor antiretroviral medication adherence (AOR 7.3, 95% CI 2.57– 20.79) and for patients who had had a first high viral load (≥ 10,000 copies/mL, (AOR 5, 95% CI 1.86– 13.56) and a history of opportunistic infection (AOR 3.7, 95% CI 1.11– 8.44) compared with their counterparts.Conclusion: Poor antiretroviral medication adherence during adherence-enhancement counseling session, first viral load ≥ 10,000 copies/mL, and recent history of opportunistic infection were predictors of virological failure. Therefore, efforts should be strengthened to improve adherence to antiretroviral medication, which helps to boost immunity and suppress viral replication.Keywords: HIV/AIDS, adherence-enhancement counseling, virological failure, case–control, Ethiopia
format	article
author	Bisetegn G Arefaynie M Mohammed A Fentaw Z Muche A Dewau R Seid Y
author_facet	Bisetegn G Arefaynie M Mohammed A Fentaw Z Muche A Dewau R Seid Y
author_sort	Bisetegn G
title	Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
title_short	Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
title_full	Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
title_fullStr	Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
title_full_unstemmed	Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia
title_sort	predictors of virological failure after adherence-enhancement counseling among first-line adults living with hiv/aids in kombolcha town, northeast ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/21c290a0621f460dbd89608d82cdf009
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Predictors of Virological Failure after Adherence-Enhancement Counseling among First-Line Adults Living with HIV/AIDS in Kombolcha Town, Northeast Ethiopia

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