Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis

Background: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relati...

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Autores principales:	Chao Han, Xi-Kun Han, Fang-Chao Liu, Jian-Feng Huang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2017
Materias:	Peripheral vascular disease Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/21c3504d31424ed78121ea17f2835d36
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spelling	oai:doaj.org-article:21c3504d31424ed78121ea17f2835d362021-12-02T14:14:04ZEthnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis2095-882X10.1016/j.cdtm.2017.07.002https://doaj.org/article/21c3504d31424ed78121ea17f2835d362017-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17300105https://doaj.org/toc/2095-882XBackground: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities. Methods: We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio (OR) with a 95% confidence interval (CI), regardless of between-study heterogeneity. Results: A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled ORs for the association between ACE I/D polymorphism and PVD risk were not statistically significant in the overall population under all genetic models. In further ethnicity-stratified analyses, we found a statistically significant association of ACE I/D polymorphism with PVD susceptibility in Asians under most models. However, the association among Caucasians did not reach statistical significance. Conclusion: ACE I/D polymorphism might be associated with susceptibility to PVD in the Asian population, but there was no clear evidence indicating a similar significant relationship among Caucasians.Chao HanXi-Kun HanFang-Chao LiuJian-Feng HuangKeAi Communications Co., Ltd.articlePeripheral vascular diseaseAngiotensin-converting enzymeInsertion/deletion polymorphismMeta-analysisMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 4, Pp 230-241 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Peripheral vascular disease Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis Medicine (General) R5-920
spellingShingle	Peripheral vascular disease Angiotensin-converting enzyme Insertion/deletion polymorphism Meta-analysis Medicine (General) R5-920 Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
description	Background: Several studies have investigated the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities. Methods: We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies. Random-effect models were applied to estimate the pooled odds ratio (OR) with a 95% confidence interval (CI), regardless of between-study heterogeneity. Results: A total of 13 studies with 1966 cases and 6129 controls were included in this meta-analysis. The pooled ORs for the association between ACE I/D polymorphism and PVD risk were not statistically significant in the overall population under all genetic models. In further ethnicity-stratified analyses, we found a statistically significant association of ACE I/D polymorphism with PVD susceptibility in Asians under most models. However, the association among Caucasians did not reach statistical significance. Conclusion: ACE I/D polymorphism might be associated with susceptibility to PVD in the Asian population, but there was no clear evidence indicating a similar significant relationship among Caucasians.
format	article
author	Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang
author_facet	Chao Han Xi-Kun Han Fang-Chao Liu Jian-Feng Huang
author_sort	Chao Han
title	Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
title_short	Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
title_full	Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
title_fullStr	Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
title_full_unstemmed	Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis
title_sort	ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: a meta-analysis
publisher	KeAi Communications Co., Ltd.
publishDate	2017
url	https://doaj.org/article/21c3504d31424ed78121ea17f2835d36
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Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis

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