Recanalization strategies in childhood stroke in Germany

Abstract Childhood arterial ischemic stroke (CAIS) is a rare event. Diverse etiologies, risk factors, symptoms and stroke mimics hamper obtaining a fast diagnosis and implementing immediate recanalization strategies. Over a period of 3 years (2015–2017), the data of 164 pediatric patients (> 28 d...

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Autores principales:	Martin Olivieri, Anna-Lisa Sorg, Raphael Weinberger, Karin Kurnik, Christoph Bidlingmaier, Sabrina Juranek, Florian Hoffmann, Karl Reiter, Michaela Bonfert, Moritz Tacke, Ingo Borggraefe, Florian Heinen, Lucia Gerstl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21c477051612449eb47783ccb484dd56
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spelling	oai:doaj.org-article:21c477051612449eb47783ccb484dd562021-12-02T17:45:17ZRecanalization strategies in childhood stroke in Germany10.1038/s41598-021-92533-02045-2322https://doaj.org/article/21c477051612449eb47783ccb484dd562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92533-0https://doaj.org/toc/2045-2322Abstract Childhood arterial ischemic stroke (CAIS) is a rare event. Diverse etiologies, risk factors, symptoms and stroke mimics hamper obtaining a fast diagnosis and implementing immediate recanalization strategies. Over a period of 3 years (2015–2017), the data of 164 pediatric patients (> 28 days of life-18 years) with a first episode of AIS were submitted to a hospital-based nationwide surveillance system for rare disorders (ESPED). We report a subgroup analysis of patients who have undergone recanalization therapy and compare these data with those of the whole group. Twenty-eight patients (17%) with a median age of 12.2 years (range 3.3–16.9) received recanalization therapy. Hemiparesis, facial weakness and speech disturbance were the main presenting symptoms. The time from onset of symptoms to confirmation of diagnosis was significantly shorter in the intervention group (4.1 h vs. 20.4 h, p ≤ 0.0001). Only in one patient occurred a minor bleed. Cardiac disease as predisposing risk factor was more common in the recanalization group. Recanalization therapies are feasible and increasingly applied in children with AIS. High awareness, timely diagnosis and a large amount of expertise may improve time to treatment and make hyperacute therapy an option for more patients.Martin OlivieriAnna-Lisa SorgRaphael WeinbergerKarin KurnikChristoph BidlingmaierSabrina JuranekFlorian HoffmannKarl ReiterMichaela BonfertMoritz TackeIngo BorggraefeFlorian HeinenLucia GerstlNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Olivieri Anna-Lisa Sorg Raphael Weinberger Karin Kurnik Christoph Bidlingmaier Sabrina Juranek Florian Hoffmann Karl Reiter Michaela Bonfert Moritz Tacke Ingo Borggraefe Florian Heinen Lucia Gerstl Recanalization strategies in childhood stroke in Germany
description	Abstract Childhood arterial ischemic stroke (CAIS) is a rare event. Diverse etiologies, risk factors, symptoms and stroke mimics hamper obtaining a fast diagnosis and implementing immediate recanalization strategies. Over a period of 3 years (2015–2017), the data of 164 pediatric patients (> 28 days of life-18 years) with a first episode of AIS were submitted to a hospital-based nationwide surveillance system for rare disorders (ESPED). We report a subgroup analysis of patients who have undergone recanalization therapy and compare these data with those of the whole group. Twenty-eight patients (17%) with a median age of 12.2 years (range 3.3–16.9) received recanalization therapy. Hemiparesis, facial weakness and speech disturbance were the main presenting symptoms. The time from onset of symptoms to confirmation of diagnosis was significantly shorter in the intervention group (4.1 h vs. 20.4 h, p ≤ 0.0001). Only in one patient occurred a minor bleed. Cardiac disease as predisposing risk factor was more common in the recanalization group. Recanalization therapies are feasible and increasingly applied in children with AIS. High awareness, timely diagnosis and a large amount of expertise may improve time to treatment and make hyperacute therapy an option for more patients.
format	article
author	Martin Olivieri Anna-Lisa Sorg Raphael Weinberger Karin Kurnik Christoph Bidlingmaier Sabrina Juranek Florian Hoffmann Karl Reiter Michaela Bonfert Moritz Tacke Ingo Borggraefe Florian Heinen Lucia Gerstl
author_facet	Martin Olivieri Anna-Lisa Sorg Raphael Weinberger Karin Kurnik Christoph Bidlingmaier Sabrina Juranek Florian Hoffmann Karl Reiter Michaela Bonfert Moritz Tacke Ingo Borggraefe Florian Heinen Lucia Gerstl
author_sort	Martin Olivieri
title	Recanalization strategies in childhood stroke in Germany
title_short	Recanalization strategies in childhood stroke in Germany
title_full	Recanalization strategies in childhood stroke in Germany
title_fullStr	Recanalization strategies in childhood stroke in Germany
title_full_unstemmed	Recanalization strategies in childhood stroke in Germany
title_sort	recanalization strategies in childhood stroke in germany
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/21c477051612449eb47783ccb484dd56
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Recanalization strategies in childhood stroke in Germany

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