Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain

Abstract Recent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism...

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Autores principales:	Myeounghoon Cha, Sun Woo Um, Minjee Kwon, Taick Sang Nam, Bae Hwan Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/21ce1588ed4a498cb17f040d70e04e31
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spelling	oai:doaj.org-article:21ce1588ed4a498cb17f040d70e04e312021-12-02T12:32:02ZRepetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain10.1038/s41598-017-08208-22045-2322https://doaj.org/article/21ce1588ed4a498cb17f040d70e04e312017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08208-2https://doaj.org/toc/2045-2322Abstract Recent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism of the effects of MCS using an animal model of neuropathic pain. After 10 daily sessions of MCS, repetitive MCS reduced mechanical allodynia and contributed to neuronal changes in the anterior cingulate cortex (ACC). Interestingly, inhibition of protein kinase M zeta (PKMζ), a regulator of synaptic plasticity, in the ACC blocked the effects of repetitive MCS. Histological and molecular studies showed a significantly increased level of glial fibrillary acidic protein (GFAP) expression in the ACC after peripheral neuropathy, and neither MCS treatment nor ZIP administration affected this increase. These results suggest that repetitive MCS can attenuate the mechanical allodynia in neuropathic pain, and that the activation of PKMζ in the ACC may play a role in the modulation of neuropathic pain via MCS.Myeounghoon ChaSun Woo UmMinjee KwonTaick Sang NamBae Hwan LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myeounghoon Cha Sun Woo Um Minjee Kwon Taick Sang Nam Bae Hwan Lee Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
description	Abstract Recent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism of the effects of MCS using an animal model of neuropathic pain. After 10 daily sessions of MCS, repetitive MCS reduced mechanical allodynia and contributed to neuronal changes in the anterior cingulate cortex (ACC). Interestingly, inhibition of protein kinase M zeta (PKMζ), a regulator of synaptic plasticity, in the ACC blocked the effects of repetitive MCS. Histological and molecular studies showed a significantly increased level of glial fibrillary acidic protein (GFAP) expression in the ACC after peripheral neuropathy, and neither MCS treatment nor ZIP administration affected this increase. These results suggest that repetitive MCS can attenuate the mechanical allodynia in neuropathic pain, and that the activation of PKMζ in the ACC may play a role in the modulation of neuropathic pain via MCS.
format	article
author	Myeounghoon Cha Sun Woo Um Minjee Kwon Taick Sang Nam Bae Hwan Lee
author_facet	Myeounghoon Cha Sun Woo Um Minjee Kwon Taick Sang Nam Bae Hwan Lee
author_sort	Myeounghoon Cha
title	Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
title_short	Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
title_full	Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
title_fullStr	Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
title_full_unstemmed	Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
title_sort	repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/21ce1588ed4a498cb17f040d70e04e31
work_keys_str_mv	AT myeounghooncha repetitivemotorcortexstimulationreinforcesthepainmodulationcircuitsofperipheralneuropathicpain AT sunwooum repetitivemotorcortexstimulationreinforcesthepainmodulationcircuitsofperipheralneuropathicpain AT minjeekwon repetitivemotorcortexstimulationreinforcesthepainmodulationcircuitsofperipheralneuropathicpain AT taicksangnam repetitivemotorcortexstimulationreinforcesthepainmodulationcircuitsofperipheralneuropathicpain AT baehwanlee repetitivemotorcortexstimulationreinforcesthepainmodulationcircuitsofperipheralneuropathicpain
_version_	1718394205198352384

Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain

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