PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

The prognostic value of tumor necrosis factor-alfa (TNFα), a pro-inflammatory cytokine was studied in 140 patients with a newly diagnosed chronic lymphocytic leukemia (CLL). TNFα contents in blood serum was determined using ELISA method. A significant increase of serum TNFα was shown in patients wit...

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Autores principales:	E. N. Zotina, T. P. Zagoskina, V. I. Shardakov, A. V. Yovdy, G. A. Zaitseva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	chronic lymphocytic leukemia cytokines tumor necrosis factor-alpha prognosis overall survival Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/21ce1f035d114e6182dde3c3631951f2
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spelling	oai:doaj.org-article:21ce1f035d114e6182dde3c3631951f22021-11-18T08:03:45ZPROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA1563-06252313-741X10.15789/1563-0625-2016-5-489-494https://doaj.org/article/21ce1f035d114e6182dde3c3631951f22016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1075https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe prognostic value of tumor necrosis factor-alfa (TNFα), a pro-inflammatory cytokine was studied in 140 patients with a newly diagnosed chronic lymphocytic leukemia (CLL). TNFα contents in blood serum was determined using ELISA method. A significant increase of serum TNFα was shown in patients with newly diagnosed CLL, as compared to healthy individuals. Dependence of the cytokine concentration on clnical stage and course of disease was revealed: the highest levels of serum TNFα were registered in patients with advanced disease and/or CLL progression. Distinct correlations were revealed between the studied cytokine amounts and clinical laboratory parameters reflecting the cell proliferative activity and tumor clone size. Immunochemotherapy was accompanied by a significant reduction of TNFα levels. According to the data from multivariate regression analysis. TNFα level of at the time of the diagnosis was an independent predictor of overall survival. Hence, TNFα plays an important role in CLL pathogenesis and may be used as an additional predictive factor for CLL outcomes.E. N. ZotinaT. P. ZagoskinaV. I. ShardakovA. V. YovdyG. A. ZaitsevaSPb RAACIarticlechronic lymphocytic leukemiacytokinestumor necrosis factor-alphaprognosisoverall survivalImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 489-494 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic lymphocytic leukemia cytokines tumor necrosis factor-alpha prognosis overall survival Immunologic diseases. Allergy RC581-607
spellingShingle	chronic lymphocytic leukemia cytokines tumor necrosis factor-alpha prognosis overall survival Immunologic diseases. Allergy RC581-607 E. N. Zotina T. P. Zagoskina V. I. Shardakov A. V. Yovdy G. A. Zaitseva PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
description	The prognostic value of tumor necrosis factor-alfa (TNFα), a pro-inflammatory cytokine was studied in 140 patients with a newly diagnosed chronic lymphocytic leukemia (CLL). TNFα contents in blood serum was determined using ELISA method. A significant increase of serum TNFα was shown in patients with newly diagnosed CLL, as compared to healthy individuals. Dependence of the cytokine concentration on clnical stage and course of disease was revealed: the highest levels of serum TNFα were registered in patients with advanced disease and/or CLL progression. Distinct correlations were revealed between the studied cytokine amounts and clinical laboratory parameters reflecting the cell proliferative activity and tumor clone size. Immunochemotherapy was accompanied by a significant reduction of TNFα levels. According to the data from multivariate regression analysis. TNFα level of at the time of the diagnosis was an independent predictor of overall survival. Hence, TNFα plays an important role in CLL pathogenesis and may be used as an additional predictive factor for CLL outcomes.
format	article
author	E. N. Zotina T. P. Zagoskina V. I. Shardakov A. V. Yovdy G. A. Zaitseva
author_facet	E. N. Zotina T. P. Zagoskina V. I. Shardakov A. V. Yovdy G. A. Zaitseva
author_sort	E. N. Zotina
title	PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
title_short	PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
title_full	PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
title_fullStr	PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
title_full_unstemmed	PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
title_sort	prognostic value of tumor necrosis factor-alpha in patients with chronic lymphocytic leukemia
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/21ce1f035d114e6182dde3c3631951f2
work_keys_str_mv	AT enzotina prognosticvalueoftumornecrosisfactoralphainpatientswithchroniclymphocyticleukemia AT tpzagoskina prognosticvalueoftumornecrosisfactoralphainpatientswithchroniclymphocyticleukemia AT vishardakov prognosticvalueoftumornecrosisfactoralphainpatientswithchroniclymphocyticleukemia AT avyovdy prognosticvalueoftumornecrosisfactoralphainpatientswithchroniclymphocyticleukemia AT gazaitseva prognosticvalueoftumornecrosisfactoralphainpatientswithchroniclymphocyticleukemia
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PROGNOSTIC VALUE OF TUMOR NECROSIS FACTOR-ALPHA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

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