Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt.
<h4>Backgrounds</h4>With 10% of the general population aged 15-59 years chronically infected with hepatitis C virus (HCV), Egypt is the country with the highest HCV prevalence worldwide. Healthcare workers (HCWs) are therefore at particularly high risk of HCV infection. Our aim was to st...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/21daf44d26dc48ad88d38084e2899d88 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:21daf44d26dc48ad88d38084e2899d88 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:21daf44d26dc48ad88d38084e2899d882021-11-18T07:55:23ZFrequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt.1932-620310.1371/journal.pone.0057835https://doaj.org/article/21daf44d26dc48ad88d38084e2899d882013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469082/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Backgrounds</h4>With 10% of the general population aged 15-59 years chronically infected with hepatitis C virus (HCV), Egypt is the country with the highest HCV prevalence worldwide. Healthcare workers (HCWs) are therefore at particularly high risk of HCV infection. Our aim was to study HCV infection risk after occupational blood exposure among HCWs in Cairo.<h4>Methodology/principal findings</h4>The study was conducted in 2008-2010 at Ain Shams University Hospital, Cairo. HCWs reporting an occupational blood exposure at screening, having neither anti-HCV antibodies (anti-HCV) nor HCV RNA, and exposed to a HCV RNA positive patient, were enrolled in a 6-month prospective cohort with follow-up visits at weeks 2, 4, 8, 12 and 24. During follow-up, anti-HCV, HCV RNA and ALT were tested. Among 597 HCWs who reported a blood exposure, anti-HCV prevalence at screening was 7.2%, not different from that of the general population of Cairo after age-standardization (11.6% and 10.4% respectively, p = 0.62). The proportion of HCV viremia among index patients was 37%. Of 73 HCWs exposed to HCV RNA from index patients, nine (12.3%; 95%CI, 5.8-22.1%) presented transient viremia, the majority of which occurred within the first two weeks after exposure. None of the workers presented seroconversion or elevation of ALT.<h4>Conclusions/significance</h4>HCWs of a general University hospital in Cairo were exposed to a highly viremic patient population. They experienced frequent occupational blood exposures, particularly in early stages of training. These exposures resulted in transient viremic episodes without established infection. These findings call for further investigation of potential immune protection against HCV persistence in this high risk group.Aline MunierDiaa MarzoukFlorence AbravanelMai El-DalySylvia TaylorRasha MamdouhWaleed Salah EldinHanan Ezz El-ArabDalia Gaber SosMohamed MomenOmar OkashaLenaig Le FoulerMostafa El-HosiniJacques IzopetMona RafikMatthew AlbertMohamed Abdel-HamidMostafa Kamal MohamedElisabeth Delarocque-AstagneauArnaud FontanetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57835 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Aline Munier Diaa Marzouk Florence Abravanel Mai El-Daly Sylvia Taylor Rasha Mamdouh Waleed Salah Eldin Hanan Ezz El-Arab Dalia Gaber Sos Mohamed Momen Omar Okasha Lenaig Le Fouler Mostafa El-Hosini Jacques Izopet Mona Rafik Matthew Albert Mohamed Abdel-Hamid Mostafa Kamal Mohamed Elisabeth Delarocque-Astagneau Arnaud Fontanet Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| description |
<h4>Backgrounds</h4>With 10% of the general population aged 15-59 years chronically infected with hepatitis C virus (HCV), Egypt is the country with the highest HCV prevalence worldwide. Healthcare workers (HCWs) are therefore at particularly high risk of HCV infection. Our aim was to study HCV infection risk after occupational blood exposure among HCWs in Cairo.<h4>Methodology/principal findings</h4>The study was conducted in 2008-2010 at Ain Shams University Hospital, Cairo. HCWs reporting an occupational blood exposure at screening, having neither anti-HCV antibodies (anti-HCV) nor HCV RNA, and exposed to a HCV RNA positive patient, were enrolled in a 6-month prospective cohort with follow-up visits at weeks 2, 4, 8, 12 and 24. During follow-up, anti-HCV, HCV RNA and ALT were tested. Among 597 HCWs who reported a blood exposure, anti-HCV prevalence at screening was 7.2%, not different from that of the general population of Cairo after age-standardization (11.6% and 10.4% respectively, p = 0.62). The proportion of HCV viremia among index patients was 37%. Of 73 HCWs exposed to HCV RNA from index patients, nine (12.3%; 95%CI, 5.8-22.1%) presented transient viremia, the majority of which occurred within the first two weeks after exposure. None of the workers presented seroconversion or elevation of ALT.<h4>Conclusions/significance</h4>HCWs of a general University hospital in Cairo were exposed to a highly viremic patient population. They experienced frequent occupational blood exposures, particularly in early stages of training. These exposures resulted in transient viremic episodes without established infection. These findings call for further investigation of potential immune protection against HCV persistence in this high risk group. |
| format |
article |
| author |
Aline Munier Diaa Marzouk Florence Abravanel Mai El-Daly Sylvia Taylor Rasha Mamdouh Waleed Salah Eldin Hanan Ezz El-Arab Dalia Gaber Sos Mohamed Momen Omar Okasha Lenaig Le Fouler Mostafa El-Hosini Jacques Izopet Mona Rafik Matthew Albert Mohamed Abdel-Hamid Mostafa Kamal Mohamed Elisabeth Delarocque-Astagneau Arnaud Fontanet |
| author_facet |
Aline Munier Diaa Marzouk Florence Abravanel Mai El-Daly Sylvia Taylor Rasha Mamdouh Waleed Salah Eldin Hanan Ezz El-Arab Dalia Gaber Sos Mohamed Momen Omar Okasha Lenaig Le Fouler Mostafa El-Hosini Jacques Izopet Mona Rafik Matthew Albert Mohamed Abdel-Hamid Mostafa Kamal Mohamed Elisabeth Delarocque-Astagneau Arnaud Fontanet |
| author_sort |
Aline Munier |
| title |
Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| title_short |
Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| title_full |
Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| title_fullStr |
Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| title_full_unstemmed |
Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. |
| title_sort |
frequent transient hepatitis c viremia without seroconversion among healthcare workers in cairo, egypt. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/21daf44d26dc48ad88d38084e2899d88 |
| work_keys_str_mv |
AT alinemunier frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT diaamarzouk frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT florenceabravanel frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT maieldaly frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT sylviataylor frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT rashamamdouh frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT waleedsalaheldin frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT hananezzelarab frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT daliagabersos frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT mohamedmomen frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT omarokasha frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT lenaiglefouler frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT mostafaelhosini frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT jacquesizopet frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT monarafik frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT matthewalbert frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT mohamedabdelhamid frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT mostafakamalmohamed frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT elisabethdelarocqueastagneau frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt AT arnaudfontanet frequenttransienthepatitiscviremiawithoutseroconversionamonghealthcareworkersincairoegypt |
| _version_ |
1718422717660659712 |